ID   C9JD84_HUMAN            Unreviewed;      1340 AA.
AC   C9JD84;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   SubName: Full=Latent-transforming growth factor beta-binding protein 1 {ECO:0000313|Ensembl:ENSP00000384373};
GN   Name=LTBP1 {ECO:0000313|Ensembl:ENSP00000384373};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384373, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000384373, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000384373}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC019127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL133244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JD84; -.
DR   SMR; C9JD84; -.
DR   EPD; C9JD84; -.
DR   jPOST; C9JD84; -.
DR   MaxQB; C9JD84; -.
DR   PeptideAtlas; C9JD84; -.
DR   PRIDE; C9JD84; -.
DR   Ensembl; ENST00000402934; ENSP00000384373; ENSG00000049323.
DR   UCSC; uc061hyz.1; human.
DR   EuPathDB; HostDB:ENSG00000049323.15; -.
DR   HGNC; HGNC:6714; LTBP1.
DR   OpenTargets; ENSG00000049323; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410Z7XK; LUCA.
DR   GeneTree; ENSGT00940000155823; -.
DR   HOGENOM; HOG000293153; -.
DR   ChiTaRS; LTBP1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000049323; Expressed in 241 organ(s), highest expression level in descending thoracic aorta.
DR   ExpressionAtlas; C9JD84; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 3.90.290.10; -; 4.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF07645; EGF_CA; 13.
DR   Pfam; PF00683; TB; 4.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00179; EGF_CA; 16.
DR   SUPFAM; SSF57184; SSF57184; 3.
DR   SUPFAM; SSF57581; SSF57581; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 11.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 13.
DR   PROSITE; PS01187; EGF_CA; 6.
DR   PROSITE; PS51364; TB; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JD84,
KW   ECO:0000213|PeptideAtlas:C9JD84};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1340       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997187.
FT   DOMAIN       73    105       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      231    276       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN      300    337       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      351    397       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN      494    531       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      536    577       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      659    699       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      700    740       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      741    781       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      782    822       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      823    864       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      865    902       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      966   1020       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN     1086   1122       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1143   1196       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN     1240   1276       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1281   1325       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID     77     87       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID     95    104       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1340 AA;  147007 MW;  B80241DDCA2C1A0E CRC64;
     MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN
     GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ASVPKLYQHS
     QQPGKALGTH VIHSTHTLPL TVTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP
     TGQKTKEAQP GQSQVSYQGL PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS
     QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD
     INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK GPCYRLVSSG
     RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAKEE PVEALTFSRE HGPGVAEPEV
     ATAPPEKEIP SLDQEKTKLE PGQPQLSPGI STIHLHPQFP VVIEKTSPPV PVEVAPEAST
     SSASQVIAPT QVTEINECTV NPDICGAGHC INLPVRYTCI CYEGYRFSEQ QRKCVDIDEC
     TQVQHLCSQG RCENTEGSFL CICPAGFMAS EEGTNCIDVD ECLRPDVCGE GHCVNTVGAF
     RCEYCDSGYR MTQRGRCEDI DECLNPSTCP DEQCVNSPGS YQCVPCTEGF RGWNGQCLDV
     DECLEPNVCA NGDCSNLEGS YMCSCHKGYT RTPDHKHCRD IDECQQGNLC VNGQCKNTEG
     SFRCTCGQGY QLSAAKDQCE DIDECQHRHL CAHGQCRNTE GSFQCVCDQG YRASGLGDHC
     EDINECLEDK SVCQRGDCIN TAGSYDCTCP DGFQLDDNKT CQDINECEHP GLCGPQGECL
     NTEGSFHCVC QQGFSISADG RTCEDIDECV NNTVCDSHGF CDNTAGSFRC LCYQGFQAPQ
     DGQGCVDVNE CELLSGVCGE AFCENVEGSF LCVCADENQE YSPMTGQCRS RTSTDVDVDQ
     PKEEKKECYY NLNDASLCDN VLAPNVTKQE CCCTSGVGWG DNCEIFPCPV LGTAEFTEMC
     PKGKGFVPAG ESSSEAGGEN YKDADECLLF GQEICKNGFC LNTRPGYECY CKQGTYYDPV
     KLQCFDMDEC QDPSSCIDGQ CVNTEGSYNC FCTHPMVLDA SEKRCIRPAE SNEQIEETDV
     YQDLCWEHLS DEYVCSRPLV GKQTTYTECC CLYGEAWGMQ CALCPLKDSD DYAQLCNIPV
     TGRRQPYGRD ALVDFSEQYT PEADPYFIQD RFLNSFEELQ AEECGILNGC ENGRCVRVQE
     GYTCDCFDGY HLDTAKMTCV DVNECDELNN RMSLCKNAKC INTDGSYKCL CLPGYVPSDK
     PNYCTPLNTA LNLEKDSDLE
//