ID   C9JCP7_HUMAN            Unreviewed;       579 AA.
AC   C9JCP7;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 74.
DE   SubName: Full=Vasoactive intestinal polypeptide receptor 2 {ECO:0000313|Ensembl:ENSP00000384497};
GN   Name=VIPR2 {ECO:0000313|Ensembl:ENSP00000384497};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384497, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000384497, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000384497}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00547938}.
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DR   EMBL; AC004863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF027390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JCP7; -.
DR   PRIDE; C9JCP7; -.
DR   Ensembl; ENST00000402066; ENSP00000384497; ENSG00000106018.
DR   UCSC; uc064jtt.1; human.
DR   EuPathDB; HostDB:ENSG00000106018.13; -.
DR   HGNC; HGNC:12695; VIPR2.
DR   OpenTargets; ENSG00000106018; -.
DR   eggNOG; KOG4564; Eukaryota.
DR   eggNOG; ENOG410XRS2; LUCA.
DR   GeneTree; ENSGT00940000158089; -.
DR   HOGENOM; HOG000008249; -.
DR   PhylomeDB; C9JCP7; -.
DR   ChiTaRS; VIPR2; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106018; Expressed in 127 organ(s), highest expression level in esophagus.
DR   ExpressionAtlas; C9JCP7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004999; F:vasoactive intestinal polypeptide receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR001571; GPCR_2_VIP_rcpt.
DR   InterPro; IPR002284; GPCR_2_VIP_rcpt_2.
DR   PANTHER; PTHR12011:SF27; PTHR12011:SF27; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PRINTS; PR00491; VASOACTVEIPR.
DR   PRINTS; PR01155; VIP2RECEPTOR.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JCP7};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    579       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996423.
FT   TRANSMEM    269    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    301    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    382    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    498    519       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      178    254       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      267    520       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   579 AA;  64043 MW;  D0DDC25D12F19085 CRC64;
     MRTLLPPALL TCWLLAPVSA PATPAPRRLG PGSPLPRRAL LPPVFAFLPG AGARAGSGRG
     SGVARGPELP PGEREALSSG PAGLRDSGWE AACALPRAPP SGVCWKRDRF FLDASTMSSF
     GAVPGAGSCG RLRGLRVSRG DRGWRWPQMP LGPSLYLLVN SIHPECRFHL EIQEEETKCA
     ELLRSQTEKH KACSGVWDNI TCWRPANVGE TVTVPCPKVF SNFYSKAGNI SKNCTSDGWS
     ETFPDFVDAC GYSDPEDESK ITFYILVKAI YTLGYSVSLM SLATGSIILC LFRKLHCTRN
     YIHLNLFLSF ILRAISVLVK DDVLYSSSGT LHCPDQPSSW VGCKLSLVFL QYCIMANFFW
     LLVEGLYLHT LLVAMLPPRR CFLAYLLIGW GLPTVCIGAW TAARLYLEDT GCWDTNDHSV
     PWWVIRIPIL ISIIVNFVLF ISIIRILLQK LTSPDVGGND QSQYKRLAKS TLLLIPLFGV
     HYMVFAVFPI SISSKYQILF ELCLGSFQGL VVAVLYCFLN SEVQCELKRK WRSRCPTPSA
     SRDYRVCGSS FSRNGSEGAL QFHRGSRAQS FLQTETSVI
//