ID   C9JCM6_HUMAN            Unreviewed;       169 AA.
AC   C9JCM6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Mesoderm-specific transcript homolog protein {ECO:0000313|Ensembl:ENSP00000396504};
DE   Flags: Fragment;
GN   Name=MEST {ECO:0000313|Ensembl:ENSP00000396504};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396504, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000396504, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000396504}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC007938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JCM6; -.
DR   ESTHER; human-MEST; MEST-like.
DR   jPOST; C9JCM6; -.
DR   PeptideAtlas; C9JCM6; -.
DR   PRIDE; C9JCM6; -.
DR   Ensembl; ENST00000458161; ENSP00000396504; ENSG00000106484.
DR   UCSC; uc064iau.1; human.
DR   EuPathDB; HostDB:ENSG00000106484.14; -.
DR   HGNC; HGNC:7028; MEST.
DR   OpenTargets; ENSG00000106484; -.
DR   eggNOG; ENOG410INNB; Eukaryota.
DR   eggNOG; ENOG4111G38; LUCA.
DR   GeneTree; ENSGT00510000047602; -.
DR   HOGENOM; HOG000049677; -.
DR   ChiTaRS; MEST; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106484; Expressed in 234 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JCM6; baseline and differential.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JCM6,
KW   ECO:0000213|MaxQB:C9JCM6, ECO:0000213|PeptideAtlas:C9JCM6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    169       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997179.
FT   DOMAIN       62    153       AB hydrolase-1.
FT                                {ECO:0000259|Pfam:PF00561}.
FT   NON_TER     169    169       {ECO:0000313|Ensembl:ENSP00000396504}.
SQ   SEQUENCE   169 AA;  19454 MW;  F265AF5B4EC2A2B6 CRC64;
     MREWWVQVGL LAVPLLAAYL HIPPPQLSPA LHSWKSSGKF FTYKGLRIFY QDSVGVVGSP
     EIVVLLHGFP TSSYDWYKIW EGLTLRFHRV IALDFLGFGF SDKPRPHHYS IFEQASIVEA
     LLRHLGLQNR RINLLSHDYG DIVAQELLYR YKQNRSGRLT IKSLCLSNG
//