ID   C9JCF5_HUMAN            Unreviewed;       182 AA.
AC   C9JCF5;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Lactotransferrin {ECO:0000313|Ensembl:ENSP00000395234};
DE   Flags: Fragment;
GN   Name=LTF {ECO:0000313|Ensembl:ENSP00000395234};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395234, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000395234, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000395234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC098613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JCF5; -.
DR   SMR; C9JCF5; -.
DR   jPOST; C9JCF5; -.
DR   PeptideAtlas; C9JCF5; -.
DR   PRIDE; C9JCF5; -.
DR   Ensembl; ENST00000431944; ENSP00000395234; ENSG00000012223.
DR   UCSC; uc062jac.1; human.
DR   EuPathDB; HostDB:ENSG00000012223.12; -.
DR   HGNC; HGNC:6720; LTF.
DR   OpenTargets; ENSG00000012223; -.
DR   eggNOG; ENOG410IEAI; Eukaryota.
DR   eggNOG; ENOG410XQ36; LUCA.
DR   GeneTree; ENSGT00940000156055; -.
DR   HOGENOM; HOG000213562; -.
DR   ChiTaRS; LTF; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000012223; Expressed in 159 organ(s), highest expression level in trachea.
DR   ExpressionAtlas; C9JCF5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:InterPro.
DR   GO; GO:0001817; P:regulation of cytokine production; IEA:InterPro.
DR   InterPro; IPR030684; Lactotransferrin.
DR   InterPro; IPR001156; Transferrin-like_dom.
DR   InterPro; IPR018195; Transferrin_Fe_BS.
DR   PANTHER; PTHR11485:SF33; PTHR11485:SF33; 1.
DR   Pfam; PF00405; Transferrin; 1.
DR   PRINTS; PR00422; TRANSFERRIN.
DR   SMART; SM00094; TR_FER; 1.
DR   PROSITE; PS00205; TRANSFERRIN_LIKE_1; 1.
DR   PROSITE; PS51408; TRANSFERRIN_LIKE_4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JCF5,
KW   ECO:0000213|PeptideAtlas:C9JCF5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    182       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013175260.
FT   DOMAIN       36    182       Transferrin-like.
FT                                {ECO:0000259|PROSITE:PS51408}.
FT   NON_TER     182    182       {ECO:0000313|Ensembl:ENSP00000395234}.
SQ   SEQUENCE   182 AA;  20344 MW;  528720131FE9362E CRC64;
     MKLVFLVLLF LGALGFLWMP FIRQPGLCLA GRRRSVQWCA VSQPEATKCF QWQRNMRKVR
     GPPVSCIKRD SPIQCIQAIA ENRADAVTLD GGFIYEAGLA PYKLRPVAAE VYGTERQPRT
     HYYAVAVVKK GGSFQLNELQ GLKSCHTGLR RTAGWNVPIG TLRPFLNWTG PPEPIEAAVA
     RF
//