ID   C9JC72_HUMAN            Unreviewed;       133 AA.
AC   C9JC72;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Complement component C6 {ECO:0000313|Ensembl:ENSP00000396565};
DE   Flags: Fragment;
GN   Name=C6 {ECO:0000313|Ensembl:ENSP00000396565};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396565, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000396565, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000396565}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC008863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JC72; -.
DR   jPOST; C9JC72; -.
DR   PeptideAtlas; C9JC72; -.
DR   PRIDE; C9JC72; -.
DR   Ensembl; ENST00000417809; ENSP00000396565; ENSG00000039537.
DR   UCSC; uc063dgg.1; human.
DR   EuPathDB; HostDB:ENSG00000039537.13; -.
DR   HGNC; HGNC:1339; C6.
DR   OpenTargets; ENSG00000039537; -.
DR   eggNOG; ENOG410IDXP; Eukaryota.
DR   eggNOG; ENOG410YJ70; LUCA.
DR   GeneTree; ENSGT00940000156814; -.
DR   ChiTaRS; C6; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000039537; Expressed in 117 organ(s), highest expression level in liver.
DR   ExpressionAtlas; C9JC72; baseline and differential.
DR   GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR   GO; GO:0006956; P:complement activation; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 2.
DR   InterPro; IPR037563; Complement_C6.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR19325:SF23; PTHR19325:SF23; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   SMART; SM00209; TSP1; 2.
DR   SUPFAM; SSF82895; SSF82895; 2.
DR   PROSITE; PS50092; TSP1; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JC72,
KW   ECO:0000213|PeptideAtlas:C9JC72};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    133       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996420.
FT   NON_TER     133    133       {ECO:0000313|Ensembl:ENSP00000396565}.
SQ   SEQUENCE   133 AA;  15254 MW;  D2063E2C205262FE CRC64;
     MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI VVDKYYQENF
     CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ SKVRSVLRPS QFGGQPCTAP
     LVAFQPCIPS KLC
//