ID   C9JBG5_HUMAN            Unreviewed;       855 AA.
AC   C9JBG5;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=SID1 transmembrane family member 2 {ECO:0000313|Ensembl:ENSP00000278951};
DE   SubName: Full=SID1 transmembrane family, member 2, isoform CRA_a {ECO:0000313|EMBL:EAW67283.1};
GN   Name=SIDT2 {ECO:0000313|EMBL:EAW67283.1,
GN   ECO:0000313|Ensembl:ENSP00000278951};
GN   ORFNames=hCG_2039721 {ECO:0000313|EMBL:EAW67283.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000278951, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|EMBL:EAW67283.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:EAW67283.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000213|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [4] {ECO:0000313|Ensembl:ENSP00000278951, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [5] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6] {ECO:0000313|Ensembl:ENSP00000278951}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [7] {ECO:0000313|Ensembl:ENSP00000486114}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
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DR   EMBL; AP005018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67283.1; -; Genomic_DNA.
DR   UniGene; Hs.712144; -.
DR   jPOST; C9JBG5; -.
DR   MaxQB; C9JBG5; -.
DR   PRIDE; C9JBG5; -.
DR   Ensembl; ENST00000278951; ENSP00000278951; ENSG00000149577.
DR   Ensembl; ENST00000628876; ENSP00000486114; ENSG00000149577.
DR   UCSC; uc001pqg.3; human.
DR   EuPathDB; HostDB:ENSG00000149577.15; -.
DR   HGNC; HGNC:24272; SIDT2.
DR   OpenTargets; ENSG00000149577; -.
DR   eggNOG; ENOG410IF6Z; Eukaryota.
DR   eggNOG; ENOG410XPBN; LUCA.
DR   GeneTree; ENSGT00390000010091; -.
DR   HOGENOM; HOG000020635; -.
DR   OMA; DEACGGP; -.
DR   ChiTaRS; SIDT2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149577; Expressed in 227 organ(s), highest expression level in endothelial cell.
DR   ExpressionAtlas; C9JBG5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051033; F:RNA transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0033227; P:dsRNA transport; IEA:InterPro.
DR   InterPro; IPR025958; SID1_TM_fam.
DR   PANTHER; PTHR12185; PTHR12185; 1.
DR   Pfam; PF13965; SID-1_RNA_chan; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JBG5,
KW   ECO:0000213|PeptideAtlas:C9JBG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    855       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086878.
FT   TRANSMEM    292    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    470    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    524    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    570    591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    628    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    653    675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    710    729       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    735    756       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    768    788       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   855 AA;  96729 MW;  0D1EDAD826ABEF61 CRC64;
     MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN
     RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GMFQRKYLYQ KVERTLCQPP
     TKNESEIQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE
     GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS
     NSFYVVVVVK TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
     LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG SSPYEGYNYG
     SFENVSGSTD GLVDSAGTGD LSYGYQGHDQ FKRRLPSGQM RQLCIAMGRS FEPVGTRPRV
     DSMSSVEEDD YDTLTDIDSD KNVIRTKQYL YVADLARKDK RVLRKKYQIY FWNIATIAVF
     YALPVVQLVI TYQTVVNVTG NQDICYYNFL CAHPLGNLSA FNNILSNLGY ILLGLLFLLI
     ILQREINHNR ALLRNDLCAL ECGIPKHFGL FYAMGTALMM EGLLSACYHV CPNYTNFQFD
     TSFMYMIAGL CMLKLYQKRH PDINASAYSA YACLAIVIFF SVLGVVFGKG NTAFWIVFSI
     IHIIATLLLS TQLYYMGRWK LDSGIFRRIL HVLYTDCIRQ CSGPLYVDRM VLLVMGNVIN
     WSLAAYGLIM RPNDFASYLL AIGICNLLLY FAFYIIMKLR SGERIKLIPL LCIVCTSVVW
     GFALFFFFQG LSTWQKTPAE SREHNRDCIL LDFFDDHDIW HFLSSIAMFG SFLVSGPPGR
     AGWVREGSSC LLLCG
//