ID   C9JA99_HUMAN            Unreviewed;       904 AA.
AC   C9JA99;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   SubName: Full=Protocadherin alpha-13 {ECO:0000313|Ensembl:ENSP00000386821};
GN   Name=PCDHA13 {ECO:0000313|Ensembl:ENSP00000386821};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386821, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386821, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386821}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00533980}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00533980}.
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DR   EMBL; AC005609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JA99; -.
DR   jPOST; C9JA99; -.
DR   MaxQB; C9JA99; -.
DR   PeptideAtlas; C9JA99; -.
DR   PRIDE; C9JA99; -.
DR   Ensembl; ENST00000409494; ENSP00000386821; ENSG00000239389.
DR   UCSC; uc003lie.2; human.
DR   EuPathDB; HostDB:ENSG00000239389.7; -.
DR   HGNC; HGNC:8667; PCDHA13.
DR   OpenTargets; ENSG00000239389; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000165479; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000239389; Expressed in 42 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; C9JA99; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR031904; Cadherin_CBD.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF15974; Cadherin_tail; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS00049551};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00441280};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00441280,
KW   ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    904       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996537.
FT   TRANSMEM    698    718       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    131       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      155    240       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      264    348       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      372    453       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      477    563       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      594    676       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   904 AA;  97431 MW;  21E1A61E519CD5E9 CRC64;
     MLSSWQGGPR PRQLLLWLLI LAAWETGSGQ LHYSVPEEAK HGTFVGRIAQ DLGLELAELV
     PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE
     VKVRDINDNP PIFPESKKRI IIAESRPPET RFPLDGASDA DIGVNSALTY RLDPNDYFTL
     DAQNSLEQMS SLSLVLRKTL DREEIQEHSL LLTASDGGKP ELTGTVQLLI TILDVNDNAP
     EFYQSVYKVT VLENAFNGTL VIKLNATDPD DGTNGDIVYS FRRPVWPAVV YAFTINPNNG
     EIRTKGKLDF EEKKLYEISV EAVDKGNIPM AGHCTLLVEV LDVNDNAPEV TITSLSLPIR
     EDTQPSAIIA LISVSDRDSG SNGQVTCTLT PHVPFKLVST YKNYYSLVLD SALDRESVSA
     YELVVTARDG GSPSLWATAS VSVGVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAQ
     DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDS
     GVPPLGSNVT LQVFVLDEND NAPALLTPGA GSAGGTVSEL MPRSVGAGHV VAKVRAVDAD
     SGYNAWLSYE LQLAAVGARI PFRVGLYTGE ISTTRPLDEV DAPHHRLLVL VKDHGEPALT
     ATATVLLSLV ESGQAPQASS RASAGAVGPE AALVDVNVYL IIAICAVSSL LVLTLLLYTA
     LRCSAPPTEG ACAPGKPTLV CSSAAGSWSY SQQRRPRVCS GEGPHKTDLM AFSPSLPPCL
     GSAEGTGQRE EDSECLKEPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP
     TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PEPKKQTQVS FLLRRKGEAS
     QPRQ
//