ID   C9J9B4_HUMAN            Unreviewed;       125 AA.
AC   C9J9B4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|Ensembl:ENSP00000391930};
DE   Flags: Fragment;
GN   Name=ADAM10 {ECO:0000313|Ensembl:ENSP00000391930};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391930, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000391930, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000391930}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J9B4; -.
DR   jPOST; C9J9B4; -.
DR   MaxQB; C9J9B4; -.
DR   PeptideAtlas; C9J9B4; -.
DR   PRIDE; C9J9B4; -.
DR   Ensembl; ENST00000439637; ENSP00000391930; ENSG00000137845.
DR   UCSC; uc059jry.1; human.
DR   EuPathDB; HostDB:ENSG00000137845.14; -.
DR   HGNC; HGNC:188; ADAM10.
DR   OpenTargets; ENSG00000137845; -.
DR   GeneTree; ENSGT00940000160579; -.
DR   ChiTaRS; ADAM10; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137845; Expressed in 242 organ(s), highest expression level in testis.
DR   ExpressionAtlas; C9J9B4; baseline and differential.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   InterPro; IPR027053; ADAM_10.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   PANTHER; PTHR11905:SF4; PTHR11905:SF4; 2.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9J9B4,
KW   ECO:0000213|MaxQB:C9J9B4, ECO:0000213|PeptideAtlas:C9J9B4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    125       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997663.
FT   DOMAIN       35    112       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
FT   NON_TER     125    125       {ECO:0000313|Ensembl:ENSP00000391930}.
SQ   SEQUENCE   125 AA;  14531 MW;  21BAF17B94B20F54 CRC64;
     MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL
     RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYDY PHKYGPQGGC
     ADHSV
//