ID   C9J8I8_HUMAN            Unreviewed;       214 AA.
AC   C9J8I8;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 66.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
DE   Flags: Fragment;
GN   Name=WNT5A {ECO:0000313|Ensembl:ENSP00000418184};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418184, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418184, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000418184}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|RuleBase:RU003500,
CC       ECO:0000256|SAAS:SAAS00681827}.
CC   -!- SIMILARITY: Belongs to the Wnt family.
CC       {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
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DR   EMBL; AC121764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J8I8; -.
DR   jPOST; C9J8I8; -.
DR   PeptideAtlas; C9J8I8; -.
DR   PRIDE; C9J8I8; -.
DR   Ensembl; ENST00000482079; ENSP00000418184; ENSG00000114251.
DR   UCSC; uc062ktz.1; human.
DR   EuPathDB; HostDB:ENSG00000114251.13; -.
DR   HGNC; HGNC:12784; WNT5A.
DR   OpenTargets; ENSG00000114251; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   eggNOG; ENOG410XQZ1; LUCA.
DR   GeneTree; ENSGT00940000158894; -.
DR   HOGENOM; HOG000039529; -.
DR   ChiTaRS; WNT5A; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114251; Expressed in 199 organ(s), highest expression level in endometrium.
DR   ExpressionAtlas; C9J8I8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR026538; Wnt5a.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083909};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
KW   Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J8I8,
KW   ECO:0000213|PeptideAtlas:C9J8I8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00083931};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083917}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    214       Protein Wnt. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997654.
FT   NON_TER     214    214       {ECO:0000313|Ensembl:ENSP00000418184}.
SQ   SEQUENCE   214 AA;  23974 MW;  00F7957D7BAA5C86 CRC64;
     MAGSAMSSKF FLVALAIFFS FAQVVIEANS WWSLGMNNPV QMSEVYIIGA QPLCSQLAGL
     SQGQKKLCHL YQDHMQYIGE GAKTGIKECQ YQFRHRRWNC STVDNTSVFG RVMQIGSRET
     AFTYAVSAAG VVNAMSRACR EGELSTCGCS RAARPKDLPR DWLWGGCGDN IDYGYRFAKE
     FVDARERERI HAKGSYESAR ILMNLHNNEA GRRV
//