ID   C9J6F6_HUMAN            Unreviewed;       307 AA.
AC   C9J6F6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   13-FEB-2019, entry version 64.
DE   RecName: Full=Aquaporin {ECO:0000256|PIRNR:PIRNR017529};
GN   Name=AQP12A {ECO:0000313|Ensembl:ENSP00000405899};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405899, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405899, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000405899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC       neutral solutes across cell membranes.
CC       {ECO:0000256|PIRNR:PIRNR017529}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|PIRNR:PIRNR017529, ECO:0000256|RuleBase:RU000477}.
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DR   EMBL; AC011298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J6F6; -.
DR   STRING; 9606.ENSP00000384894; -.
DR   PaxDb; C9J6F6; -.
DR   PeptideAtlas; C9J6F6; -.
DR   PRIDE; C9J6F6; -.
DR   Ensembl; ENST00000429564; ENSP00000405899; ENSG00000184945.
DR   UCSC; uc061ujk.1; human.
DR   EuPathDB; HostDB:ENSG00000184945.13; -.
DR   HGNC; HGNC:19941; AQP12A.
DR   OpenTargets; ENSG00000184945; -.
DR   eggNOG; ENOG410IJA3; Eukaryota.
DR   eggNOG; ENOG4111GCP; LUCA.
DR   GeneTree; ENSGT00530000063816; -.
DR   HOGENOM; HOG000034023; -.
DR   OMA; QFPCSGH; -.
DR   PhylomeDB; C9J6F6; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000184945; Expressed in 46 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; C9J6F6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR016697; Aquaporin_11/12.
DR   InterPro; IPR023265; Aquaporin_12.
DR   InterPro; IPR000425; MIP.
DR   PANTHER; PTHR21191:SF8; PTHR21191:SF8; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PIRSF; PIRSF017529; Aquaporin_11/12; 1.
DR   PRINTS; PR02025; AQUAPORIN12.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU000477};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU000477};
KW   Transport {ECO:0000256|RuleBase:RU000477}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    307       Aquaporin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997135.
SQ   SEQUENCE   307 AA;  32645 MW;  91141B909DA17627 CRC64;
     MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AVGAVQLGPC CLEMRTLVEL
     GPWAGDFGPD LLLTLLFLLF LAHGVTLDGA SANPTVSLQE FLMAEQSLPG TLLKLAAQGL
     GMQAACTLMR LCWAWELSDL HLLQSLMAQS CSSALRTSVP HGALVEAACA FCFHLTLLHL
     RHSPPAYSGP AVALLVTVTA YTAGPFTSAF FNPALAASVT FACSGHTLLE YVQVYWLGPL
     TGMVLAVLLH QGRLPHLFQR NLFYGQKNKY RAPRGKPAPA SGDTQTPAKG SSVREPGRSG
     VEGPHSS
//