ID   C9J6C4_HUMAN            Unreviewed;       196 AA.
AC   C9J6C4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 63.
DE   SubName: Full=Interleukin-5 receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000398117};
DE   Flags: Fragment;
GN   Name=IL5RA {ECO:0000313|Ensembl:ENSP00000398117};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398117, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000398117, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000398117}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC022002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J6C4; -.
DR   SMR; C9J6C4; -.
DR   MaxQB; C9J6C4; -.
DR   PeptideAtlas; C9J6C4; -.
DR   PRIDE; C9J6C4; -.
DR   Ensembl; ENST00000445701; ENSP00000398117; ENSG00000091181.
DR   UCSC; uc062gcb.1; human.
DR   EuPathDB; HostDB:ENSG00000091181.19; -.
DR   HGNC; HGNC:6017; IL5RA.
DR   OpenTargets; ENSG00000091181; -.
DR   eggNOG; ENOG410IJ36; Eukaryota.
DR   eggNOG; ENOG4111ZG2; LUCA.
DR   GeneTree; ENSGT00940000160890; -.
DR   HOGENOM; HOG000070224; -.
DR   ChiTaRS; IL5RA; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000091181; Expressed in 85 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; C9J6C4; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9J6C4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    196       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996529.
FT   DOMAIN      131    196       IL6Ra-bind. {ECO:0000259|Pfam:PF09240}.
FT   NON_TER     196    196       {ECO:0000313|Ensembl:ENSP00000398117}.
SQ   SEQUENCE   196 AA;  22046 MW;  C129F43D0B9CFD7C CRC64;
     MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN
     VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA
     PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE
     ECQEYSKDTL GRNIAC
//