ID   C9J5M1_HUMAN            Unreviewed;       303 AA.
AC   C9J5M1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Lysyl oxidase homolog 3 {ECO:0000313|Ensembl:ENSP00000398260};
DE   Flags: Fragment;
GN   Name=LOXL3 {ECO:0000313|Ensembl:ENSP00000398260};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398260, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000398260, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000398260}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AC005033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J5M1; -.
DR   jPOST; C9J5M1; -.
DR   PeptideAtlas; C9J5M1; -.
DR   PRIDE; C9J5M1; -.
DR   Ensembl; ENST00000413469; ENSP00000398260; ENSG00000115318.
DR   UCSC; uc061kyt.1; human.
DR   EuPathDB; HostDB:ENSG00000115318.11; -.
DR   HGNC; HGNC:13869; LOXL3.
DR   OpenTargets; ENSG00000115318; -.
DR   eggNOG; ENOG410IE2X; Eukaryota.
DR   eggNOG; ENOG410XSN1; LUCA.
DR   GeneTree; ENSGT00940000158157; -.
DR   HOGENOM; HOG000220841; -.
DR   ChiTaRS; LOXL3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115318; Expressed in 160 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; C9J5M1; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 2.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 2.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 2.
DR   SUPFAM; SSF56487; SSF56487; 2.
DR   PROSITE; PS50287; SRCR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J5M1,
KW   ECO:0000213|PeptideAtlas:C9J5M1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    303       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996397.
FT   DOMAIN       44    145       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      169    282       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID     70    134       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID     83    144       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    114    124       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    248    258       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     303    303       {ECO:0000313|Ensembl:ENSP00000398260}.
SQ   SEQUENCE   303 AA;  32948 MW;  52C2B8CE0BFD8313 CRC64;
     MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
     QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
     VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR
     PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS
     FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
     PQG
//