ID   C9J511_HUMAN            Unreviewed;       171 AA.
AC   C9J511;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 68.
DE   SubName: Full=Thyroid peroxidase {ECO:0000313|Ensembl:ENSP00000390994};
DE   Flags: Fragment;
GN   Name=TPO {ECO:0000313|Ensembl:ENSP00000390994};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390994, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000390994, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000390994}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000486958}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC105450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC141930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; C9J511; -.
DR   PRIDE; C9J511; -.
DR   Ensembl; ENST00000423320; ENSP00000390994; ENSG00000115705.
DR   Ensembl; ENST00000628844; ENSP00000486958; ENSG00000277603.
DR   UCSC; uc061gbp.1; human.
DR   EuPathDB; HostDB:ENSG00000115705.20; -.
DR   HGNC; HGNC:12015; TPO.
DR   OpenTargets; ENSG00000115705; -.
DR   eggNOG; KOG2408; Eukaryota.
DR   eggNOG; ENOG410XPZ3; LUCA.
DR   GeneTree; ENSGT00940000158104; -.
DR   HOGENOM; HOG000016084; -.
DR   ChiTaRS; TPO; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115705; Expressed in 86 organ(s), highest expression level in right lobe of thyroid gland.
DR   ExpressionAtlas; C9J511; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004447; F:iodide peroxidase activity; IEA:InterPro.
DR   GO; GO:0006590; P:thyroid hormone generation; IEA:InterPro.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR029589; TPO.
DR   PANTHER; PTHR11475:SF60; PTHR11475:SF60; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9J511};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    171       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086881.
FT   NON_TER     171    171       {ECO:0000313|Ensembl:ENSP00000390994}.
SQ   SEQUENCE   171 AA;  18925 MW;  CD9A748E04087E29 CRC64;
     MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR
     NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS
     EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN T
//