ID   C9J4T6_HUMAN            Unreviewed;        95 AA.
AC   C9J4T6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 79.
DE   RecName: Full=Multifunctional fusion protein {ECO:0000256|RuleBase:RU361149, ECO:0000256|RuleBase:RU364007};
DE   Includes:
DE     RecName: Full=Interleukin-8 {ECO:0000256|RuleBase:RU364007};
DE              Short=IL-8 {ECO:0000256|RuleBase:RU364007};
DE     AltName: Full=C-X-C motif chemokine 8 {ECO:0000256|RuleBase:RU364007};
DE     AltName: Full=Chemokine (C-X-C motif) ligand 8 {ECO:0000256|RuleBase:RU364007};
DE   Includes:
DE     RecName: Full=C-X-C motif chemokine {ECO:0000256|RuleBase:RU361149};
GN   Name=CXCL8 {ECO:0000256|RuleBase:RU364007,
GN   ECO:0000313|Ensembl:ENSP00000385908};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385908, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385908, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385908}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364007}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361149,
CC       ECO:0000256|SAAS:SAAS00709696}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
CC       family. {ECO:0000256|RuleBase:RU361149,
CC       ECO:0000256|SAAS:SAAS01078811}.
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DR   EMBL; AC112518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J4T6; -.
DR   SMR; C9J4T6; -.
DR   PRIDE; C9J4T6; -.
DR   Ensembl; ENST00000401931; ENSP00000385908; ENSG00000169429.
DR   UCSC; uc062xgp.1; human.
DR   EuPathDB; HostDB:ENSG00000169429.10; -.
DR   HGNC; HGNC:6025; CXCL8.
DR   OpenTargets; ENSG00000169429; -.
DR   eggNOG; ENOG410J24U; Eukaryota.
DR   eggNOG; ENOG410Z1BP; LUCA.
DR   GeneTree; ENSGT00940000160757; -.
DR   HOGENOM; HOG000220915; -.
DR   ChiTaRS; CXCL8; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000169429; Expressed in 176 organ(s), highest expression level in periodontal ligament.
DR   ExpressionAtlas; C9J4T6; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0005153; F:interleukin-8 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0042119; P:neutrophil activation; IEA:InterPro.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:InterPro.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR028469; Interleukin-8.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   PANTHER; PTHR10179:SF70; PTHR10179:SF70; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis {ECO:0000256|RuleBase:RU361149};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Cytokine {ECO:0000256|RuleBase:RU361149,
KW   ECO:0000256|SAAS:SAAS00709704};
KW   Disulfide bond {ECO:0000256|RuleBase:RU364007,
KW   ECO:0000256|SAAS:SAAS00709709};
KW   Inflammatory response {ECO:0000256|RuleBase:RU364007};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J4T6,
KW   ECO:0000213|PeptideAtlas:C9J4T6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU361149,
KW   ECO:0000256|SAAS:SAAS00709711};
KW   Signal {ECO:0000256|RuleBase:RU361149}.
FT   SIGNAL        1     22       {ECO:0000256|RuleBase:RU361149}.
FT   CHAIN        23     95       Multifunctional fusion protein.
FT                                {ECO:0000256|RuleBase:RU361149}.
FT                                /FTId=PRO_5005125873.
FT   DOMAIN       31     92       SCY. {ECO:0000259|SMART:SM00199}.
SQ   SEQUENCE   95 AA;  10697 MW;  FE89319F49724A4E CRC64;
     MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH
     CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKR
//