ID   C9J4J8_HUMAN            Unreviewed;       106 AA.
AC   C9J4J8;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=EGF-containing fibulin-like extracellular matrix protein 1 {ECO:0000313|Ensembl:ENSP00000398345};
DE   Flags: Fragment;
GN   Name=EFEMP1 {ECO:0000313|Ensembl:ENSP00000398345};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398345, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000398345, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000398345}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J4J8; -.
DR   jPOST; C9J4J8; -.
DR   MaxQB; C9J4J8; -.
DR   PeptideAtlas; C9J4J8; -.
DR   PRIDE; C9J4J8; -.
DR   Ensembl; ENST00000440439; ENSP00000398345; ENSG00000115380.
DR   UCSC; uc061jiw.1; human.
DR   EuPathDB; HostDB:ENSG00000115380.19; -.
DR   HGNC; HGNC:3218; EFEMP1.
DR   OpenTargets; ENSG00000115380; -.
DR   eggNOG; ENOG410IR77; Eukaryota.
DR   eggNOG; ENOG410YCRW; LUCA.
DR   GeneTree; ENSGT00940000157837; -.
DR   ChiTaRS; EFEMP1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115380; Expressed in 226 organ(s), highest expression level in thoracic aorta.
DR   ExpressionAtlas; C9J4J8; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005006; F:epidermal growth factor-activated receptor activity; IEA:InterPro.
DR   InterPro; IPR032973; EFEMP1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR037287; Fibulin_3/4/5.
DR   PANTHER; PTHR44074; PTHR44074; 1.
DR   PANTHER; PTHR44074:SF2; PTHR44074:SF2; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J4J8,
KW   ECO:0000213|PeptideAtlas:C9J4J8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    106       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996393.
FT   DOMAIN       44     71       EGF_CA. {ECO:0000259|Pfam:PF07645}.
FT   NON_TER     106    106       {ECO:0000313|Ensembl:ENSP00000398345}.
SQ   SEQUENCE   106 AA;  11521 MW;  BEA5B6B5EFEF6F0D CRC64;
     MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK
     CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASS
//