ID C9J4F3_HUMAN Unreviewed; 1676 AA. AC C9J4F3; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 05-DEC-2018, entry version 70. DE SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000410304}; GN Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000410304}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410304, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000410304, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000410304} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9J4F3; -. DR EPD; C9J4F3; -. DR PeptideAtlas; C9J4F3; -. DR PRIDE; C9J4F3; -. DR Ensembl; ENST00000414778; ENSP00000410304; ENSG00000150275. DR UCSC; uc057thv.1; human. DR EuPathDB; HostDB:ENSG00000150275.17; -. DR HGNC; HGNC:14674; PCDH15. DR OpenTargets; ENSG00000150275; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000156675; -. DR HOGENOM; HOG000230919; -. DR ChiTaRS; PCDH15; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; C9J4F3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0032420; C:stereocilium; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IEA:InterPro. DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR030718; Protocadherin-15. DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 4. DR Pfam; PF00028; Cadherin; 8. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 11. DR SUPFAM; SSF49313; SSF49313; 10. DR PROSITE; PS00232; CADHERIN_1; 3. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:C9J4F3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 1676 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002996517. FT TRANSMEM 1375 1397 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 64 145 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 174 263 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 304 393 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 426 507 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 531 613 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 638 715 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 739 817 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 841 924 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 948 1034 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1055 1142 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1166 1250 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 1676 AA; 186021 MW; 46EA61B17ED976EF CRC64; MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL EPVNRDFHQK FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY QGYILESAPV GATISDSLNL TSPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTQTGIT RYLTLLQPVD REEQQTYTFS ITAFDGVQES EPVIVNIQVM DANDNTPTFP EISYDVYVYT DMRPGDSVIQ LTAVDADEGS NGEITYEILV GAQGDFIINK TTGLITIAPG VEMIVGRTYA LTVQAADNAP PAERRNSICT VYIEVLPPNN QSPPRFPQLM YSLEISEAMR VGAVLLNLQA TDREGDSITY AIENGDPQRV FNLSETTGIL TLGKALDRES TDRYILIITA SDGRPDGTST ATVNIVVTDV NDNAPVFDPY LPRNLSVVEE EANAFVGQVK ATDPDAGING QVHYSLGNFN NLFRITSNGS IYTAVKLNRE VRDYYELVVV ATDGAVHPRH STLTLAIKVL DIDDNSPVFT NSTYTVLVEE NLPAGTTILQ IEAKDVDLGA NVSYRIRSPE VKHFFALHPF TGELSLLRSL DYEAFPDQEA SITFLVEAFD IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGLPA SRVRYRVDDV QFPYPASIFE VEEDSGRVIT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA TVKILVLHPG EIPRFTQEEY RPPPVSELAT KGTMVGVISA AAINQSIVYS IVSGNEEDTF GINNITGVIY VNGPLDYETR TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENNH PPVFQKKFYI GGVSEDARMF TSVLRVKATD KDTGNYSVMA YRLIIPPIKE GKEGFVVETY TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSGKADVLV SVVNQLDMQV IVSNVPPTLV EKKIEDLTEI LDRYVQEQIP GAKVVVESIG ARRHGDAFSL EDYTKCDLTV YAIDPQTNRA IDRNELFKFL DGKLLDINKD FQPYYGEGGR ILEIRTPEAV TSIKKRGESL GYTEGALLAL AFIIILCCIP AILVVLVSYR QVFKGRQAEC TKTARIQAAL PAAKPAVPAP APVAAPPPPP PPPPGAHLYE ELGDSSMYEM PQYGSRRRLL PPAGQEEYGE VVGEAEEEYE EEEWARKRMI KLVVDREYET SSTGEDSAPE CQRNRLHHPS IHSNINGNIY IAQNGSVVRT RRACLTDNLK VASPVRLGGP FKKLDKLAVT HEENVPLNTL SKGPFSTEKM NARPTLVTFA PCPVGTDNTA VKPLRNRLKS TVEQESMIDS KNIKEALEFH SDHTQSDDEE LWMGPWNNLH IPMTKL //