ID   CV046_HUMAN             Reviewed;         243 AA.
AC   C9J442;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   RecName: Full=Uncharacterized protein C22orf46;
DE   Flags: Precursor;
GN   Name=C22orf46;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW60455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; Z83840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471095; EAW60455.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC035403; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS46717.1; -.
DR   RefSeq; NP_001136436.1; NM_001142964.1.
DR   UniGene; Hs.517653; -.
DR   ProteinModelPortal; C9J442; -.
DR   SMR; C9J442; -.
DR   BioGrid; 122768; 3.
DR   iPTMnet; C9J442; -.
DR   PhosphoSitePlus; C9J442; -.
DR   BioMuta; C22orf46; -.
DR   PaxDb; C9J442; -.
DR   PRIDE; C9J442; -.
DR   ProteomicsDB; 8428; -.
DR   DNASU; 79640; -.
DR   Ensembl; ENST00000402966; ENSP00000385467; ENSG00000184208.
DR   GeneID; 79640; -.
DR   KEGG; hsa:79640; -.
DR   UCSC; uc003bax.1; human.
DR   CTD; 79640; -.
DR   EuPathDB; HostDB:ENSG00000184208.10; -.
DR   GeneCards; C22orf46; -.
DR   HGNC; HGNC:26294; C22orf46.
DR   HPA; HPA052741; -.
DR   neXtProt; NX_C9J442; -.
DR   OpenTargets; ENSG00000184208; -.
DR   PharmGKB; PA165378333; -.
DR   eggNOG; ENOG410IIN7; Eukaryota.
DR   eggNOG; ENOG4111836; LUCA.
DR   GeneTree; ENSGT00900000141218; -.
DR   HOGENOM; HOG000206575; -.
DR   InParanoid; C9J442; -.
DR   OMA; QTHLICK; -.
DR   OrthoDB; 177612at2759; -.
DR   PhylomeDB; C9J442; -.
DR   ChiTaRS; C22orf46; human.
DR   GenomeRNAi; 79640; -.
DR   PRO; PR:C9J442; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000184208; Expressed in 133 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   Genevisible; C9J442; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031715; DUF4727.
DR   PANTHER; PTHR22379; PTHR22379; 1.
DR   Pfam; PF15856; DUF4727; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18    243       Uncharacterized protein C22orf46.
FT                                /FTId=PRO_0000394218.
FT   CARBOHYD     30     30       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    165    165       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   243 AA;  27532 MW;  08DAD81D145A1F89 CRC64;
     MLLSLLGACA VVGPFHGPEW EPVQGLLSQN HSCRDPQCCG NLLVLCLFLV WQVRHCWHQV
     TRTRFSTRNV IKVPLQKRAV PSMRCETVFK LTPEFFSPGK SRGLDSQQCA QRQRWGYRRS
     LQESWAQNLL SPQHPCPGPP SGVHTHSEPI FCTTSISNTC LLPQNSSWKA WQVPWCLHDG
     QTRPALDMCQ EMEQLLLHSQ ERLVSLEPVI SVRSRPTSMT LTTSLPNLLS AERLQFCPQR
     APA
//