ID   C9J3V9_HUMAN            Unreviewed;       185 AA.
AC   C9J3V9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=N-chimaerin {ECO:0000313|Ensembl:ENSP00000410496};
DE   Flags: Fragment;
GN   Name=CHN1 {ECO:0000313|Ensembl:ENSP00000410496};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410496, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000410496, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000410496}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J3V9; -.
DR   SMR; C9J3V9; -.
DR   jPOST; C9J3V9; -.
DR   MaxQB; C9J3V9; -.
DR   PeptideAtlas; C9J3V9; -.
DR   PRIDE; C9J3V9; -.
DR   Ensembl; ENST00000413882; ENSP00000410496; ENSG00000128656.
DR   UCSC; uc061pwc.1; human.
DR   EuPathDB; HostDB:ENSG00000128656.13; -.
DR   HGNC; HGNC:1943; CHN1.
DR   OpenTargets; ENSG00000128656; -.
DR   eggNOG; KOG1453; Eukaryota.
DR   eggNOG; ENOG410YM3I; LUCA.
DR   GeneTree; ENSGT00940000153726; -.
DR   HOGENOM; HOG000231926; -.
DR   ChiTaRS; CHN1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000128656; Expressed in 219 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; C9J3V9; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00733152};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J3V9,
KW   ECO:0000213|PeptideAtlas:C9J3V9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00732909}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    185       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996382.
FT   DOMAIN       23     73       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN       86    185       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   NON_TER     185    185       {ECO:0000313|Ensembl:ENSP00000410496}.
SQ   SEQUENCE   185 AA;  20914 MW;  A905975531CD8735 CRC64;
     MATMGLLMLL TLAASPHFLS ICFHHVCVHT FRGPHWCEYC ANFMWGLIAQ GVKCADCGLN
     VHKQCSKMVP NDCKPDLKHV KKVYSCDLTT LVKAHTTKRP MVVDMCIREI ESRGLNSEGL
     YRVSGFSDLI EDVKMAFDRD GEKADISVNM YEDINIITGA LKLYFRDLPI PLITYDAYPK
     FIESA
//