ID   C9J2B6_HUMAN            Unreviewed;       958 AA.
AC   C9J2B6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=Netrin receptor UNC5D {ECO:0000313|Ensembl:ENSP00000412652};
GN   Name=UNC5D {ECO:0000313|Ensembl:ENSP00000412652};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412652, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412652, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000412652}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC012215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC013302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J2B6; -.
DR   PRIDE; C9J2B6; -.
DR   Ensembl; ENST00000416672; ENSP00000412652; ENSG00000156687.
DR   UCSC; uc064lwl.1; human.
DR   EuPathDB; HostDB:ENSG00000156687.10; -.
DR   HGNC; HGNC:18634; UNC5D.
DR   OpenTargets; ENSG00000156687; -.
DR   eggNOG; KOG1480; Eukaryota.
DR   eggNOG; ENOG410XRS6; LUCA.
DR   GeneTree; ENSGT00940000153287; -.
DR   HOGENOM; HOG000060306; -.
DR   OMA; QQPLHCA; -.
DR   OrthoDB; 334938at2759; -.
DR   PhylomeDB; C9J2B6; -.
DR   ChiTaRS; UNC5D; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000156687; Expressed in 103 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; C9J2B6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; PTHR12582; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF82895; SSF82895; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9J2B6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    958       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997582.
FT   TRANSMEM    385    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      166    244       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      547    687       ZU5. {ECO:0000259|PROSITE:PS51145}.
SQ   SEQUENCE   958 AA;  106591 MW;  E50106180BB3CF40 CRC64;
     MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP
     DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR
     QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC
     RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR
     RSLSATVVVY VNGGWSSWTE WSACNVRCGR GWQKRSRTCT NPAPLNGGAF CEGMSVQKIT
     CTSLCPVDGS WEVWSEWSVC SPECEHLRIR ECTAPPPRNG GKFCEGLSQE SENCTDGLCI
     LDKKPLHEIK PQRWSRRGIE NASDIALYSG LGAAVVAVAV LVIGVTLYRR SQSDYGVDVI
     DSSALTGGFQ TFNFKTVRQG NSLLLNSAMQ PDLTVSRTYS GPICLQDPLD KELMTESSLF
     NPLSDIKVKV QSSFMVSLGV SERAEYHGKN HSRTFPHGNN HSFSTMHPRN KMPYIQNLSS
     LPTRTELRTT GVFGHLGGRL VMPNTGVSLL IPHGAIPEEN SWEIYMSINQ GEPSLQSDGS
     EVLLSPEVTC GPPDMIVTTP FALTIPHCAD VSSEHWNIHL KKRTQQGKWE EVMSVEDEST
     SCYCLLDPFA CHVLLDSFGT YALTGEPITD CAVKQLKVAV FGCMSCNSLD YNLRVYCVDN
     TPCAFQEVVS DERHQGGQLL EEPKLLHFKG NTFSLQISVL DIPPFLWRIK PFTACQEVPF
     SRVWCSNRQP LHCAFSLERY TPTTTQLSCK ICIRQLKGHE QILQVQTSIL ESERETITFF
     AQEDSTFPAQ TGPKAFKIPY SIRQRICATF DTPNAKGKDW QMLAQKNSIN RNLSYFATQS
     SPSAVILNLW EARHQHDGDL DSLACALEEI GRTHTKLSNI SESQLDEADF NYSRQNGL
//