ID   C9J1I0_HUMAN            Unreviewed;       886 AA.
AC   C9J1I0;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=Netrin receptor UNC5D {ECO:0000313|Ensembl:ENSP00000392739};
GN   Name=UNC5D {ECO:0000313|Ensembl:ENSP00000392739};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392739, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000392739, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000392739}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC012215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC013302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011542705.1; XM_011544403.2.
DR   UniGene; Hs.238889; -.
DR   UniGene; Hs.720206; -.
DR   ProteinModelPortal; C9J1I0; -.
DR   PeptideAtlas; C9J1I0; -.
DR   PRIDE; C9J1I0; -.
DR   Ensembl; ENST00000420357; ENSP00000392739; ENSG00000156687.
DR   GeneID; 137970; -.
DR   UCSC; uc064lwk.1; human.
DR   CTD; 137970; -.
DR   EuPathDB; HostDB:ENSG00000156687.10; -.
DR   HGNC; HGNC:18634; UNC5D.
DR   OpenTargets; ENSG00000156687; -.
DR   GeneTree; ENSGT00940000153287; -.
DR   HOGENOM; HOG000060306; -.
DR   OrthoDB; 334938at2759; -.
DR   ChiTaRS; UNC5D; human.
DR   GenomeRNAi; 137970; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000156687; Expressed in 103 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; C9J1I0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; PTHR12582; 2.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF82895; SSF82895; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9J1I0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    886       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997268.
FT   TRANSMEM    313    336       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      166    244       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      475    615       ZU5. {ECO:0000259|PROSITE:PS51145}.
SQ   SEQUENCE   886 AA;  98472 MW;  D1E6DBFA5D8857A1 CRC64;
     MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP
     DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR
     QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC
     RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR
     RSLSATVVVY VDGSWEVWSE WSVCSPECEH LRIRECTAPP PRNGGKFCEG LSQESENCTD
     GLCILGIENA SDIALYSGLG AAVVAVAVLV IGVTLYRRSQ SDYGVDVIDS SALTGGFQTF
     NFKTVRQGNS LLLNSAMQPD LTVSRTYSGP ICLQDPLDKE LMTESSLFNP LSDIKVKVQS
     SFMVSLGVSE RAEYHGKNHS RTFPHGNNHS FSTMHPRNKM PYIQNLSSLP TRTELRTTGV
     FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV LLSPEVTCGP
     PDMIVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV MSVEDESTSC YCLLDPFACH
     VLLDSFGTYA LTGEPITDCA VKQLKVAVFG CMSCNSLDYN LRVYCVDNTP CAFQEVVSDE
     RHQGGQLLEE PKLLHFKGNT FSLQISVLDI PPFLWRIKPF TACQEVPFSR VWCSNRQPLH
     CAFSLERYTP TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ EDSTFPAQTG
     PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP SAVILNLWEA
     RHQHDGDLDS LACALEEIGR THTKLSNISE SQLDEADFNY SRQNGL
//