ID   C9J075_HUMAN            Unreviewed;       148 AA.
AC   C9J075;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Plasma kallikrein {ECO:0000313|Ensembl:ENSP00000412366};
DE   Flags: Fragment;
GN   Name=KLKB1 {ECO:0000313|Ensembl:ENSP00000412366};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412366, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412366, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000412366}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC110771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9J075; -.
DR   jPOST; C9J075; -.
DR   PeptideAtlas; C9J075; -.
DR   PRIDE; C9J075; -.
DR   Ensembl; ENST00000428196; ENSP00000412366; ENSG00000164344.
DR   UCSC; uc063bog.1; human.
DR   EuPathDB; HostDB:ENSG00000164344.15; -.
DR   HGNC; HGNC:6371; KLKB1.
DR   OpenTargets; ENSG00000164344; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000161669; -.
DR   HOGENOM; HOG000213704; -.
DR   ChiTaRS; KLKB1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000164344; Expressed in 150 organ(s), highest expression level in liver.
DR   ExpressionAtlas; C9J075; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007597; P:blood coagulation, intrinsic pathway; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd01100; APPLE_Factor_XI_like; 1.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR034813; Plasma_kallikrein.
DR   PANTHER; PTHR44459:SF2; PTHR44459:SF2; 1.
DR   Pfam; PF00024; PAN_1; 2.
DR   PRINTS; PR00005; APPLEDOMAIN.
DR   SMART; SM00223; APPLE; 1.
DR   PROSITE; PS50948; PAN; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9J075,
KW   ECO:0000213|PeptideAtlas:C9J075};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    148       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997077.
FT   DOMAIN       21    104       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   DOMAIN      111    148       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   NON_TER     148    148       {ECO:0000313|Ensembl:ENSP00000412366}.
SQ   SEQUENCE   148 AA;  16620 MW;  E9CE80E97F2DB638 CRC64;
     MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF
     SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD
     MRGVNFNVSK VSSVEECQKR CTSNIRCQ
//