ID   C9IYB5_HUMAN            Unreviewed;       333 AA.
AC   C9IYB5;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Metalloprotease TIKI1 {ECO:0000313|Ensembl:ENSP00000387183};
GN   Name=TRABD2A {ECO:0000313|Ensembl:ENSP00000387183};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387183, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387183, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000387183}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001294907.1; NM_001307978.1.
DR   UniGene; Hs.469134; -.
DR   ProteinModelPortal; C9IYB5; -.
DR   MaxQB; C9IYB5; -.
DR   PeptideAtlas; C9IYB5; -.
DR   PRIDE; C9IYB5; -.
DR   Ensembl; ENST00000409133; ENSP00000387183; ENSG00000186854.
DR   GeneID; 129293; -.
DR   UCSC; uc010fgc.4; human.
DR   CTD; 129293; -.
DR   EuPathDB; HostDB:ENSG00000186854.10; -.
DR   HGNC; HGNC:27013; TRABD2A.
DR   OpenTargets; ENSG00000186854; -.
DR   GeneTree; ENSGT00940000162805; -.
DR   HOGENOM; HOG000154747; -.
DR   OrthoDB; 1407303at2759; -.
DR   ChiTaRS; TRABD2A; human.
DR   GenomeRNAi; 129293; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000186854; Expressed in 121 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; C9IYB5; baseline and differential.
DR   InterPro; IPR040230; TIKI1/2-like.
DR   InterPro; IPR002816; TraB_fam.
DR   PANTHER; PTHR31120; PTHR31120; 1.
DR   Pfam; PF01963; TraB; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9IYB5,
KW   ECO:0000213|PeptideAtlas:C9IYB5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    333       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997061.
FT   COILED      192    212       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   333 AA;  38221 MW;  D661C24F3F430D60 CRC64;
     MSPWSWFLLQ TLCLLPTGAA SRRGAPGTAN CELKPQQSEL NSFLWTIKRD PPSYFFGTIH
     VPYTRVWDFI PDNSKEAFLQ SSIVYFELDL TDPYTISALT SCQMLPQGEN LQDVLPRDIY
     CRLKRHLEYV KLMMPLWMTP DQRGKGLYAD YLFNAIAGNW ERKRPVWVML MVNSLTEVDI
     KSRGVPVLDL FLAQEAERLR KQTGAVEKVE EQCHPLNGLN FSQVIFALNQ TLLQQESLRA
     GSLQIPYTTE DLIKHYNCGD LSSVILSHDS SQVPNFINAT LPPQERITAQ EIDSYLRREL
     IYKRNERIGK RVKALLEEFP DKGFFFAFGA ASQ
//