ID   C6G488_HUMAN            Unreviewed;       354 AA.
AC   C6G488;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=Alpha-2,8-sialyltransferase 8B {ECO:0000313|EMBL:ACS13735.1, ECO:0000313|Ensembl:ENSP00000437382};
GN   Name=ST8SIA2 {ECO:0000313|EMBL:ACS13735.1,
GN   ECO:0000313|Ensembl:ENSP00000437382};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACS13735.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000437382, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|EMBL:ACS13735.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST8SA2-VI-T {ECO:0000313|EMBL:ACS13735.1};
RA   Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N.,
RA   Strausberg R.L., Kirkness E.F., Rogers Y.-H., Levy S.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000437382}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
CC       {ECO:0000256|SAAS:SAAS01027238}.
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DR   EMBL; AC090985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ515842; ACS13735.1; -; Genomic_DNA.
DR   RefSeq; NP_001317345.1; NM_001330416.1.
DR   UniGene; Hs.302341; -.
DR   jPOST; C6G488; -.
DR   PeptideAtlas; C6G488; -.
DR   PRIDE; C6G488; -.
DR   Ensembl; ENST00000539113; ENSP00000437382; ENSG00000140557.
DR   GeneID; 8128; -.
DR   UCSC; uc002brb.4; human.
DR   CTD; 8128; -.
DR   EuPathDB; HostDB:ENSG00000140557.11; -.
DR   HGNC; HGNC:10870; ST8SIA2.
DR   OpenTargets; ENSG00000140557; -.
DR   GeneTree; ENSGT00940000154058; -.
DR   OrthoDB; 825014at2759; -.
DR   ChiTaRS; ST8SIA2; human.
DR   GenomeRNAi; 8128; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000140557; Expressed in 66 organ(s), highest expression level in brain.
DR   ExpressionAtlas; C6G488; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008373; F:sialyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.1480.20; -; 1.
DR   InterPro; IPR001675; Glyco_trans_29.
DR   InterPro; IPR038578; GT29-like_sf.
DR   InterPro; IPR012163; Sialyl_trans.
DR   Pfam; PF00777; Glyco_transf_29; 1.
DR   PIRSF; PIRSF005557; Sialyl_trans; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|SAAS:SAAS01027230,
KW   ECO:0000313|EMBL:ACS13735.1};
KW   Golgi apparatus {ECO:0000256|SAAS:SAAS01027226};
KW   Membrane {ECO:0000256|SAAS:SAAS01027233};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS01027230,
KW   ECO:0000313|EMBL:ACS13735.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01027233};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01027233}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    354       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086434.
FT   DISULFID    136    286       {ECO:0000256|PIRSR:PIRSR005557-2}.
SQ   SEQUENCE   354 AA;  40250 MW;  49EFB8D188472CDA CRC64;
     MQLQFRSWML AALTLLVVFL IFADISEIEE EIGAEVVING SSSPAVVDRS NESIKHNIQP
     ASSKWRHNQT LSLRIRKQIL KFLDAEKDIS VLKGTLKPGD IIHYIFDRDS TMNVSQNLYE
     LLPRTSPLKN KHFGTCAIVG NSGVLLNSGC GQEIDAHSFV IRCNLAPVQE YARDVGLKTD
     LVTMNPSVIQ RAFEDLVNAT WREKLLQRLH SLNGSILWIP AFMARGGKER VEWVNELILK
     HHVNVRTAYP SLRLLHAVRG YWLTNKVHIK RPTTGLLMYT LATRFCKQIY LYGFWPFPLD
     QNQNPVKYHY YDSLKYGYTS QASPHTMPLE FKALKSLHEQ GALKLTVGQC DGAT
//