ID   C1KBH7_HUMAN            Unreviewed;       367 AA.
AC   C1KBH7; J3KNT4;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   SubName: Full=Fibroblast growth factor receptor 1 isoform 3 {ECO:0000313|EMBL:ACO38645.1};
GN   Name=FGFR1 {ECO:0000313|EMBL:ACO38645.1,
GN   ECO:0000313|Ensembl:ENSP00000340636};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACO38645.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000340636, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|EMBL:ACO38645.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20139426; DOI=10.1093/humrep/deq006;
RA   Miura K., Miura S., Yoshiura K., Seminara S., Hamaguchi D.,
RA   Niikawa N., Masuzaki H.;
RT   "A case of Kallmann syndrome carrying a missense mutation in
RT   alternatively spliced exon 8A encoding the immunoglobulin-like domain
RT   IIIb of fibroblast growth factor receptor 1.";
RL   Hum. Reprod. 25:1076-1080(2010).
RN   [3] {ECO:0000313|Ensembl:ENSP00000340636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC087623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ809916; ACO38645.1; -; mRNA.
DR   UniGene; Hs.264887; -.
DR   jPOST; C1KBH7; -.
DR   MaxQB; C1KBH7; -.
DR   PRIDE; C1KBH7; -.
DR   Ensembl; ENST00000341462; ENSP00000340636; ENSG00000077782.
DR   UCSC; uc011lbr.4; human.
DR   EuPathDB; HostDB:ENSG00000077782.19; -.
DR   HGNC; HGNC:3688; FGFR1.
DR   OpenTargets; ENSG00000077782; -.
DR   GeneTree; ENSGT00940000155860; -.
DR   ChiTaRS; FGFR1; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000077782; Expressed in 240 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; C1KBH7; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Proteomics identification {ECO:0000213|MaxQB:C1KBH7,
KW   ECO:0000213|PeptideAtlas:C1KBH7};
KW   Receptor {ECO:0000313|EMBL:ACO38645.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    367       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014568584.
FT   DOMAIN       25    119       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      159    247       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      256    358       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   367 AA;  40729 MW;  FD978C1D2F1C2B9D CRC64;
     MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
     VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSV
     PIDALPSSED DDDDDDSSSE EKETDNTKPN PVAPYWTSPE KMEKKLHAVP AAKTVKFKCP
     SSGTPNPTLR WLKNGKEFKP DHRIGGYKVR YATWSIIMDS VVPSDKGNYT CIVENEYGSI
     NHTYQLDVVE RSPHRPILQA GLPANKTVAL GSNVEFMCKV YSDPQPHIQW LKHIEVNGSK
     IGPDNLPYVQ ILKHSGINSS DAEVLTLFNV TEAQSGEYVC KVSNYIGEAN QSAWLTVTRP
     VAKDCWS
//