ID   B9A040_HUMAN            Unreviewed;       173 AA.
AC   B9A040;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|Ensembl:ENSP00000386555};
GN   Name=IL1R1 {ECO:0000313|Ensembl:ENSP00000386555};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386555, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386555, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386555}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B9A040; -.
DR   jPOST; B9A040; -.
DR   PeptideAtlas; B9A040; -.
DR   PRIDE; B9A040; -.
DR   Ensembl; ENST00000409589; ENSP00000386555; ENSG00000115594.
DR   UCSC; uc061mls.1; human.
DR   EuPathDB; HostDB:ENSG00000115594.11; -.
DR   HGNC; HGNC:5993; IL1R1.
DR   OpenTargets; ENSG00000115594; -.
DR   eggNOG; ENOG410IQBC; Eukaryota.
DR   eggNOG; ENOG410Z3W1; LUCA.
DR   GeneTree; ENSGT00940000153278; -.
DR   HOGENOM; HOG000208479; -.
DR   HOVERGEN; HBG107085; -.
DR   ChiTaRS; IL1R1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115594; Expressed in 228 organ(s), highest expression level in palpebral conjunctiva.
DR   ExpressionAtlas; B9A040; baseline and differential.
DR   GO; GO:0004909; F:interleukin-1, type I, activating receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR004076; IL-1_rcpt_I-typ.
DR   InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR   PANTHER; PTHR11890; PTHR11890; 1.
DR   PRINTS; PR01538; INTRLEUKN1R1.
DR   PRINTS; PR01536; INTRLKN1R12F.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B9A040,
KW   ECO:0000213|PeptideAtlas:B9A040};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    173       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002881226.
FT   DOMAIN       44    110       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   173 AA;  19879 MW;  E021B49C14CAC68F CRC64;
     MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD
     DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL
     CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKVAVSRVWA TAL
//