ID   B9A025_HUMAN            Unreviewed;       586 AA.
AC   B9A025;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   SubName: Full=Lysyl oxidase homolog 3 {ECO:0000313|Ensembl:ENSP00000386545};
GN   Name=LOXL3 {ECO:0000313|Ensembl:ENSP00000386545};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386545, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386545, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AC005033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B9A025; -.
DR   jPOST; B9A025; -.
DR   PeptideAtlas; B9A025; -.
DR   PRIDE; B9A025; -.
DR   Ensembl; ENST00000409986; ENSP00000386545; ENSG00000115318.
DR   UCSC; uc010ffn.3; human.
DR   EuPathDB; HostDB:ENSG00000115318.11; -.
DR   HGNC; HGNC:13869; LOXL3.
DR   OpenTargets; ENSG00000115318; -.
DR   GeneTree; ENSGT00940000158157; -.
DR   HOGENOM; HOG000220841; -.
DR   HOVERGEN; HBG052336; -.
DR   ChiTaRS; LOXL3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115318; Expressed in 160 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; B9A025; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016641; F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 3.
DR   InterPro; IPR001695; Lysyl_oxidase.
DR   InterPro; IPR019828; Lysyl_oxidase_CS.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF01186; Lysyl_oxidase; 1.
DR   Pfam; PF00530; SRCR; 3.
DR   PRINTS; PR00074; LYSYLOXIDASE.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 3.
DR   SUPFAM; SSF56487; SSF56487; 3.
DR   PROSITE; PS00926; LYSYL_OXIDASE; 1.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:B9A025,
KW   ECO:0000213|PeptideAtlas:B9A025};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    586       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002879409.
FT   DOMAIN       44    145       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      162    262       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      272    380       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID     70    134       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID     83    144       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    114    124       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    187    251       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    200    261       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    231    241       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    347    357       {ECO:0000256|PROSITE-ProRule:PRU00196}.
SQ   SEQUENCE   586 AA;  64847 MW;  558E5D6C0061ED4D CRC64;
     MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
     QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
     VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEA RVRLKGGAHP GEGRVEVLKA
     STWGTVCDRK WDLHAASVVC RELGFGSARE ALSGARMGQG MGAIHLSEVR CSGQELSLWK
     CPHKNITAED CSHSQDAGVR CNLPYTGAET RIRLSGGRSQ HEGRVEVQIG GPGPLRWGLI
     CGDDWGTLEA MVACRQLGLG YANHGLQETW YWDSGNITEV VMSGVRCTGT ELSLDQCAHH
     GTHITCKRTG TRFTAGVICS ETASDLLLHS ALVQETAYIE DRPLHMLYCA AEENCLASSA
     RSANWPYGHR RLLRFSSQIH NLGRADFRPK AGRHSWVWHE CHGHYHSMDI FTHYDILTPN
     GTKVAEGHKA SFCLEDTECQ EDVSKRYECA NFGEQGITVG CWDLYRHDID CQWIDITDVK
     PGNYILQVVI NPNFEVAESD FTNNAMKCNC KYDGHRIWVH NCHIGI
//