ID B8ZZW4_HUMAN Unreviewed; 538 AA. AC B8ZZW4; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JAN-2019, entry version 78. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|Ensembl:ENSP00000386776}; GN Name=IL1R1 {ECO:0000313|Ensembl:ENSP00000386776}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386776, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000386776, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000386776} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456690; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001275635.1; NM_001288706.1. DR UniGene; Hs.701982; -. DR ProteinModelPortal; B8ZZW4; -. DR jPOST; B8ZZW4; -. DR MaxQB; B8ZZW4; -. DR PeptideAtlas; B8ZZW4; -. DR PRIDE; B8ZZW4; -. DR Ensembl; ENST00000409929; ENSP00000386776; ENSG00000115594. DR GeneID; 3554; -. DR UCSC; uc010fix.4; human. DR CTD; 3554; -. DR EuPathDB; HostDB:ENSG00000115594.11; -. DR HGNC; HGNC:5993; IL1R1. DR OpenTargets; ENSG00000115594; -. DR GeneTree; ENSGT00940000153278; -. DR HOGENOM; HOG000253916; -. DR HOVERGEN; HBG052103; -. DR OrthoDB; 1109920at2759; -. DR ChiTaRS; IL1R1; human. DR GenomeRNAi; 3554; -. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000115594; Expressed in 228 organ(s), highest expression level in palpebral conjunctiva. DR ExpressionAtlas; B8ZZW4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:B8ZZW4, KW ECO:0000213|PeptideAtlas:B8ZZW4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 538 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002879410. FT TRANSMEM 338 359 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 110 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 118 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 226 328 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 359 510 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 538 AA; 62029 MW; DDBACC413E9618E5 CRC64; MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK IDIVLWYRDS CYDFLPIKVL PEVLEKQCGY KLFIYGRDDY VGEDIVEVIN ENVKKSRRLI IILVRETSGF SWLGGSSEEQ IAMYNALVQD GIKVVLLELE KIQDYEKMPE SIKFIKQKHG AIRWSGDFTQ GPQSAKTRFW KNVRYHMPVQ RRSPSSKHQL LSPATKEKLQ REAHVPLG //