ID B8ZZT6_HUMAN Unreviewed; 471 AA. AC B8ZZT6; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JAN-2019, entry version 73. DE SubName: Full=Lysyl oxidase homolog 3 {ECO:0000313|Ensembl:ENSP00000387103}; GN Name=LOXL3 {ECO:0000313|Ensembl:ENSP00000387103}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387103, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000387103, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000387103} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005033; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; B8ZZT6; -. DR jPOST; B8ZZT6; -. DR PeptideAtlas; B8ZZT6; -. DR PRIDE; B8ZZT6; -. DR Ensembl; ENST00000409249; ENSP00000387103; ENSG00000115318. DR UCSC; uc061kyq.1; human. DR EuPathDB; HostDB:ENSG00000115318.11; -. DR HGNC; HGNC:13869; LOXL3. DR OpenTargets; ENSG00000115318; -. DR eggNOG; ENOG410IE2X; Eukaryota. DR eggNOG; ENOG410XSN1; LUCA. DR GeneTree; ENSGT00940000158157; -. DR HOGENOM; HOG000220841; -. DR HOVERGEN; HBG052336; -. DR ChiTaRS; LOXL3; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000115318; Expressed in 160 organ(s), highest expression level in tibia. DR ExpressionAtlas; B8ZZT6; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005507; F:copper ion binding; IEA:InterPro. DR GO; GO:0016641; F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; IEA:InterPro. DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro. DR Gene3D; 3.10.250.10; -; 3. DR InterPro; IPR001695; Lysyl_oxidase. DR InterPro; IPR001190; SRCR. DR InterPro; IPR017448; SRCR-like_dom. DR InterPro; IPR036772; SRCR-like_dom_sf. DR Pfam; PF01186; Lysyl_oxidase; 1. DR Pfam; PF00530; SRCR; 3. DR PRINTS; PR00074; LYSYLOXIDASE. DR PRINTS; PR00258; SPERACTRCPTR. DR SMART; SM00202; SR; 3. DR SUPFAM; SSF56487; SSF56487; 3. DR PROSITE; PS00420; SRCR_1; 1. DR PROSITE; PS50287; SRCR_2; 3. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196, KW ECO:0000256|SAAS:SAAS00873970}; KW Proteomics identification {ECO:0000213|MaxQB:B8ZZT6, KW ECO:0000213|PeptideAtlas:B8ZZT6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 471 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002879407. FT DOMAIN 44 145 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 169 282 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 307 365 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DISULFID 70 134 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 83 144 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 114 124 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 248 258 {ECO:0000256|PROSITE-ProRule:PRU00196}. SQ SEQUENCE 471 AA; 51882 MW; E542662CCDF7758F CRC64; MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA RMGQDVSKRY ECANFGEQGI TVGCWDLYRH DIDCQWIDIT DVKPGNYILQ VVINPNFEVA ESDFTNNAMK CNCKYDGHRI WVHNCHIGDA FSEEANRRFE RYPGQTSNQI I //