ID   B8ZZ96_HUMAN            Unreviewed;       275 AA.
AC   B8ZZ96;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 78.
DE   SubName: Full=N-chimaerin {ECO:0000313|Ensembl:ENSP00000386469};
GN   Name=CHN1 {ECO:0000313|Ensembl:ENSP00000386469};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386469, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386469, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386469}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B8ZZ96; -.
DR   jPOST; B8ZZ96; -.
DR   MaxQB; B8ZZ96; -.
DR   PeptideAtlas; B8ZZ96; -.
DR   PRIDE; B8ZZ96; -.
DR   Ensembl; ENST00000409597; ENSP00000386469; ENSG00000128656.
DR   UCSC; uc061pvy.1; human.
DR   EuPathDB; HostDB:ENSG00000128656.13; -.
DR   HGNC; HGNC:1943; CHN1.
DR   OpenTargets; ENSG00000128656; -.
DR   eggNOG; KOG1453; Eukaryota.
DR   eggNOG; ENOG410YM3I; LUCA.
DR   GeneTree; ENSGT00940000153726; -.
DR   HOGENOM; HOG000231926; -.
DR   HOVERGEN; HBG080489; -.
DR   ChiTaRS; CHN1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000128656; Expressed in 219 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; B8ZZ96; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd04372; RhoGAP_chimaerin; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037860; RhoGAP_chimaerin.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00732991};
KW   Proteomics identification {ECO:0000213|MaxQB:B8ZZ96,
KW   ECO:0000213|PeptideAtlas:B8ZZ96};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00732991};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00732991}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    275       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002879406.
FT   DOMAIN       16     71       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN       84    275       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
SQ   SEQUENCE   275 AA;  31343 MW;  4F5B8687AD2E26C3 CRC64;
     MATMGLLMLL TLAASPHFLS ICFHHVHTFR GPHWCEYCAN FMWGLIAQGV KCADCGLNVH
     KQCSKMVPND CKPDLKHVKK VYSCDLTTLV KAHTTKRPMV VDMCIREIES RGLNSEGLYR
     VSGFSDLIED VKMAFDRDGE KADISVNMYE DINIITGALK LYFRDLPIPL ITYDAYPKFI
     ESAKIMDPDE QLETLHEALK LLPPAHCETL RYLMAHLKRV TLHEKENLMN AENLGIVFGP
     TLMRSPELDA MAALNDIRYQ RLVVELLIKN EDILF
//