ID   B8ZZ84_HUMAN            Unreviewed;       591 AA.
AC   B8ZZ84;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 81.
DE   SubName: Full=Leucine-rich repeat transmembrane neuronal protein 4 {ECO:0000313|Ensembl:ENSP00000387228};
GN   Name=LRRTM4 {ECO:0000313|Ensembl:ENSP00000387228};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387228, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387228, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000387228}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC013408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC013716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317299.1; NM_001330370.1.
DR   UniGene; Hs.285782; -.
DR   ProteinModelPortal; B8ZZ84; -.
DR   jPOST; B8ZZ84; -.
DR   MaxQB; B8ZZ84; -.
DR   PRIDE; B8ZZ84; -.
DR   Ensembl; ENST00000409911; ENSP00000387228; ENSG00000176204.
DR   GeneID; 80059; -.
DR   UCSC; uc061lbo.1; human.
DR   CTD; 80059; -.
DR   EuPathDB; HostDB:ENSG00000176204.13; -.
DR   HGNC; HGNC:19411; LRRTM4.
DR   OpenTargets; ENSG00000176204; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000154909; -.
DR   HOGENOM; HOG000290681; -.
DR   HOVERGEN; HBG052362; -.
DR   OMA; TEQEYEH; -.
DR   OrthoDB; 427408at2759; -.
DR   PhylomeDB; B8ZZ84; -.
DR   ChiTaRS; LRRTM4; human.
DR   GenomeRNAi; 80059; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000176204; Expressed in 89 organ(s), highest expression level in secondary oocyte.
DR   ExpressionAtlas; B8ZZ84; baseline and differential.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 9.
DR   PROSITE; PS51450; LRR; 9.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:B8ZZ84,
KW   ECO:0000213|PeptideAtlas:B8ZZ84};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    591       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002880902.
FT   TRANSMEM    426    448       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   591 AA;  67314 MW;  6F04C6205D636F6B CRC64;
     MPGFHLITQL KGMSVVLVLL PTLLLVMLTG AQRACPKNCR CDGKIVYCES HAFADIPENI
     SGGSQGLSLR FNSIQKLKSN QFAGLNQLIW LYLDHNYISS VDEDAFQGIR RLKELILSSN
     KITYLHNKTF HPVPNLRNLD LSYNKLQTLQ SEQFKGLRKL IILHLRSNSL KTVPIRVFQD
     CRNLDFLDLG YNRLRSLSRN AFAGLLKLKE LHLEHNQFSK INFAHFPRLF NLRSIYLQWN
     RIRSISQGLT WTWSSLHNLD LSGNDIQGIE PGTFKCLPNL QKLNLDSNKL TNISQETVNA
     WISLISITLS GNMWECSRSI CPLFYWLKNF KGNKESTMIC AGPKHIQGEK VSDAVETYNI
     CSEVQVVNTE RSHLVPQTPQ KPLIIPRPTI FKPDVTQSTF ETPSPSPGFQ IPGAEQEYEH
     VSFHKIIAGS VALFLSVAMI LLVIYVSWKR YPASMKQLQQ HSLMKRRRKK ARESERQMNS
     PLQEYYVDYK PTNSETMDIS VNGSGPCTYT ISGSRECEMP HHMKPLPYYS YDQPVIGYCQ
     AHQPLHVTKG YETVSPEQDE SPGLELGRDH SFIATIARSA APAIYLERIA N
//