ID B8ZZ73_HUMAN Unreviewed; 447 AA. AC B8ZZ73; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JAN-2019, entry version 83. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|Ensembl:ENSP00000387131}; GN Name=IL1R1 {ECO:0000313|Ensembl:ENSP00000387131}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387131, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000387131, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000387131} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000386478} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456690; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; B8ZZ73; -. DR PeptideAtlas; B8ZZ73; -. DR PRIDE; B8ZZ73; -. DR Ensembl; ENST00000409288; ENSP00000386478; ENSG00000115594. DR Ensembl; ENST00000409329; ENSP00000387131; ENSG00000115594. DR Ensembl; ENST00000424272; ENSP00000415366; ENSG00000115594. DR UCSC; uc061mlr.1; human. DR EuPathDB; HostDB:ENSG00000115594.11; -. DR HGNC; HGNC:5993; IL1R1. DR OpenTargets; ENSG00000115594; -. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00940000153278; -. DR HOGENOM; HOG000253916; -. DR HOVERGEN; HBG052103; -. DR ChiTaRS; IL1R1; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000115594; Expressed in 228 organ(s), highest expression level in palpebral conjunctiva. DR ExpressionAtlas; B8ZZ73; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:B8ZZ73, KW ECO:0000213|PeptideAtlas:B8ZZ73}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 447 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014085784. FT TRANSMEM 338 359 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 44 110 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 118 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 226 328 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 383 434 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 447 AA; 51256 MW; 9B4DF1EACBA53BDC CRC64; MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEGMCVME QSKGLLL //