ID   B8ZZ48_HUMAN            Unreviewed;       141 AA.
AC   B8ZZ48;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   RecName: Full=Carbohydrate sulfotransferase {ECO:0000256|RuleBase:RU364020};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU364020};
DE   Flags: Fragment;
GN   Name=CHST10 {ECO:0000313|Ensembl:ENSP00000387121};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387121, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387121, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000387121}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU364020}; Single-pass type II membrane
CC       protein {ECO:0000256|RuleBase:RU364020}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 2 family.
CC       {ECO:0000256|RuleBase:RU364020}.
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DR   EMBL; AC012493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B8ZZ48; -.
DR   jPOST; B8ZZ48; -.
DR   PeptideAtlas; B8ZZ48; -.
DR   PRIDE; B8ZZ48; -.
DR   Ensembl; ENST00000409046; ENSP00000387121; ENSG00000115526.
DR   UCSC; uc061mif.1; human.
DR   EuPathDB; HostDB:ENSG00000115526.10; -.
DR   HGNC; HGNC:19650; CHST10.
DR   OpenTargets; ENSG00000115526; -.
DR   eggNOG; KOG4651; Eukaryota.
DR   eggNOG; ENOG4111GJR; LUCA.
DR   GeneTree; ENSGT00940000157128; -.
DR   HOGENOM; HOG000200781; -.
DR   HOVERGEN; HBG106977; -.
DR   ChiTaRS; CHST10; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115526; Expressed in 180 organ(s), highest expression level in brain.
DR   ExpressionAtlas; B8ZZ48; baseline and differential.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR018011; Carb_sulfotrans_8-10.
DR   InterPro; IPR005331; Sulfotransferase.
DR   PANTHER; PTHR12137; PTHR12137; 1.
DR   Pfam; PF03567; Sulfotransfer_2; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU364020};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycoprotein {ECO:0000256|RuleBase:RU364020};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU364020};
KW   Membrane {ECO:0000256|RuleBase:RU364020};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B8ZZ48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Signal-anchor {ECO:0000256|RuleBase:RU364020};
KW   Transferase {ECO:0000256|RuleBase:RU364020};
KW   Transmembrane {ECO:0000256|RuleBase:RU364020}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    141       Carbohydrate sulfotransferase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002879404.
FT   NON_TER     141    141       {ECO:0000313|Ensembl:ENSP00000387121}.
SQ   SEQUENCE   141 AA;  16602 MW;  ED93B6CC8507B419 CRC64;
     MHHQWLLLAA CFWVIFMFMV ASKFITLTFK DPDVYSAKQE FLFLTTMPEV RKLPEEKHIP
     EELKPTGKEL PDSQLVQPLV YMERLELIRN VCRDDALKNL SHTPVSKFVL DRIFVCDKHK
     ILFCQTPKVG NTQWKKVLIV L
//