ID   SHSA8_HUMAN             Reviewed;         397 AA.
AC   B8ZZ34; A0A087WXQ4;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   16-JAN-2019, entry version 59.
DE   RecName: Full=Protein shisa-8 {ECO:0000305};
DE   AltName: Full=Shisa family member 8 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=SHISA8 {ECO:0000312|HGNC:HGNC:18351};
GN   Synonyms=C22orf17 {ECO:0000312|HGNC:HGNC:18351};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
CC   -!- FUNCTION: May regulate trafficking and current kinetics of AMPA-
CC       type glutamate receptor (AMPAR) at synapses.
CC       {ECO:0000250|UniProtKB:J3QNX5}.
CC   -!- SUBUNIT: Interacts with AMPAR subunits GRIA1 and GRIA2.
CC       {ECO:0000250|UniProtKB:J3QNX5}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2;
CC         IsoId=B8ZZ34-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=B8ZZ34-3; Sequence=VSP_059385;
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; Z99716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS74872.1; -. [B8ZZ34-1]
DR   RefSeq; NP_001193949.1; NM_001207020.1. [B8ZZ34-1]
DR   RefSeq; XP_006724317.1; XM_006724254.3.
DR   UniGene; Hs.526704; -.
DR   ProteinModelPortal; B8ZZ34; -.
DR   STRING; 9606.ENSP00000389964; -.
DR   TCDB; 8.A.83.1.2; the shisa6 regulator of short-term neuronal synaptic plasticity (shisa) family.
DR   iPTMnet; B8ZZ34; -.
DR   PhosphoSitePlus; B8ZZ34; -.
DR   BioMuta; SHISA8; -.
DR   jPOST; B8ZZ34; -.
DR   PaxDb; B8ZZ34; -.
DR   PRIDE; B8ZZ34; -.
DR   ProteomicsDB; 7297; -.
DR   Ensembl; ENST00000621082; ENSP00000481203; ENSG00000234965. [B8ZZ34-1]
DR   GeneID; 440829; -.
DR   KEGG; hsa:440829; -.
DR   UCSC; uc062esx.1; human. [B8ZZ34-1]
DR   CTD; 440829; -.
DR   DisGeNET; 440829; -.
DR   EuPathDB; HostDB:ENSG00000234965.2; -.
DR   GeneCards; SHISA8; -.
DR   HGNC; HGNC:18351; SHISA8.
DR   HPA; HPA059173; -.
DR   MIM; 617329; gene.
DR   neXtProt; NX_B8ZZ34; -.
DR   OpenTargets; ENSG00000234965; -.
DR   PharmGKB; PA165378367; -.
DR   eggNOG; ENOG410JBKS; Eukaryota.
DR   eggNOG; ENOG4111A66; LUCA.
DR   GeneTree; ENSGT00940000163233; -.
DR   InParanoid; B8ZZ34; -.
DR   OMA; HPTATHM; -.
DR   OrthoDB; 558642at2759; -.
DR   GenomeRNAi; 440829; -.
DR   PRO; PR:B8ZZ34; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000234965; Expressed in 69 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; B8ZZ34; baseline and differential.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0032591; C:dendritic spine membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IBA:GO_Central.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774; PTHR31774; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     38       {ECO:0000255}.
FT   CHAIN        39    397       Protein shisa-8.
FT                                /FTId=PRO_0000395039.
FT   TOPO_DOM     39    138       Extracellular. {ECO:0000255}.
FT   TRANSMEM    139    159       Helical. {ECO:0000255}.
FT   TOPO_DOM    160    397       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     75     75       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     221    221       A -> AGPRTPRLARASPPGEPFMRVAPPGLAAAAAARDSE
FT                                PGPVPGAGGCGEDRLGSQPRPENGPPGSHRTASGRGLRRGD
FT                                SEGGVNRGIGPSRVSLLAP (in isoform 1).
FT                                /FTId=VSP_059385.
SQ   SEQUENCE   397 AA;  41995 MW;  A24436A7290A0E15 CRC64;
     MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC
     RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP
     PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT
     ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS ADKKRLNNAP RGSAAPGPPR
     GPRLQGGGSL TLQPDYAKYA TFKAAALKAA EAAPRDFCQR FPALEPSPRQ PPARAPRPSP
     DLPAPLDACP WAPPVYAPPA APGPYAAWTS SRPARPAPLS HPTARAFQVP RRPGHAARRQ
     FSVKMPETFN PQLPGLYGSA GRGSRYLRTN SKTEVTV
//