ID   B8YG18_HUMAN            Unreviewed;       180 AA.
AC   B8YG18;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   10-OCT-2018, entry version 67.
DE   SubName: Full=Interleukin 7 receptor isoform H5-6 {ECO:0000313|EMBL:ACL80333.1};
DE   SubName: Full=Interleukin-7 receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000427688};
GN   Name=IL7R {ECO:0000313|Ensembl:ENSP00000427688};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACL80333.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427688, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|EMBL:ACL80333.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Colle J.-H., Rose T.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ACL80333.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19494261; DOI=10.4049/jimmunol.0900190;
RA   Rose T., Lambotte O., Pallier C., Delfraissy J.F., Colle J.H.;
RT   "Identification and biochemical characterization of human plasma
RT   soluble IL-7R: lower concentrations in HIV-1-infected patients.";
RL   J. Immunol. 182:7389-7397(2009).
RN   [4] {ECO:0000313|Ensembl:ENSP00000427688}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC112204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ529208; ACL80333.1; -; mRNA.
DR   UniGene; Hs.591742; -.
DR   PRIDE; B8YG18; -.
DR   Ensembl; ENST00000514217; ENSP00000427688; ENSG00000168685.
DR   UCSC; uc063cyr.1; human.
DR   EuPathDB; HostDB:ENSG00000168685.14; -.
DR   HGNC; HGNC:6024; IL7R.
DR   OpenTargets; ENSG00000168685; -.
DR   eggNOG; ENOG410IGXR; Eukaryota.
DR   eggNOG; ENOG410YWZG; LUCA.
DR   GeneTree; ENSGT00510000048500; -.
DR   HOGENOM; HOG000089950; -.
DR   HOVERGEN; HBG055773; -.
DR   ChiTaRS; IL7R; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000168685; Expressed in 157 organ(s), highest expression level in blood.
DR   ExpressionAtlas; B8YG18; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B8YG18,
KW   ECO:0000213|PeptideAtlas:B8YG18};
KW   Receptor {ECO:0000313|EMBL:ACL80333.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014568513.
SQ   SEQUENCE   180 AA;  20380 MW;  D35859708A56DB73 CRC64;
     MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE
     DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK
     IDLTTIVKPE APFDLSVVYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTD
//