ID   B7ZL48_HUMAN            Unreviewed;       375 AA.
AC   B7ZL48;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   13-FEB-2019, entry version 90.
DE   RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE            Short=PARP {ECO:0000256|RuleBase:RU362114};
DE            EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN   Name=PARP15 {ECO:0000313|EMBL:AAI43574.1,
GN   ECO:0000313|Ensembl:ENSP00000419488};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI43574.1};
RN   [1] {ECO:0000313|EMBL:AAI43574.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:AAI43574.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419488, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000419488}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC092908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC143573; AAI43574.1; -; mRNA.
DR   RefSeq; NP_001295250.1; NM_001308321.1.
DR   UniGene; Hs.120250; -.
DR   Ensembl; ENST00000493645; ENSP00000419488; ENSG00000173200.
DR   GeneID; 165631; -.
DR   UCSC; uc011bjt.2; human.
DR   CTD; 165631; -.
DR   EuPathDB; HostDB:ENSG00000173200.12; -.
DR   HGNC; HGNC:26876; PARP15.
DR   OpenTargets; ENSG00000173200; -.
DR   eggNOG; KOG2633; Eukaryota.
DR   eggNOG; COG2110; LUCA.
DR   GeneTree; ENSGT00940000163672; -.
DR   HOGENOM; HOG000026781; -.
DR   OrthoDB; 681829at2759; -.
DR   ChiTaRS; PARP15; human.
DR   GenomeRNAi; 165631; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000173200; Expressed in 96 organ(s), highest expression level in spleen.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR002589; Macro_dom.
DR   InterPro; IPR034401; PARP15.
DR   InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR   PANTHER; PTHR14453:SF54; PTHR14453:SF54; 2.
DR   Pfam; PF01661; Macro; 1.
DR   Pfam; PF00644; PARP; 1.
DR   SMART; SM00506; A1pp; 1.
DR   PROSITE; PS51154; MACRO; 1.
DR   PROSITE; PS51059; PARP_CATALYTIC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW   NAD {ECO:0000256|RuleBase:RU362114};
KW   Proteomics identification {ECO:0000213|MaxQB:B7ZL48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU362114}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    375       Poly [ADP-ribose] polymerase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014568445.
FT   DOMAIN       59    214       Macro. {ECO:0000259|PROSITE:PS51154}.
FT   DOMAIN      179    375       PARP catalytic.
FT                                {ECO:0000259|PROSITE:PS51059}.
SQ   SEQUENCE   375 AA;  41880 MW;  676493AEF49646D5 CRC64;
     MLQRIGLIFL HNIVVVSNCF YFQAFLDEFT NWSRINPNKA RIPMAGDTQG VVGTVSKPCF
     TAYEMKIGAI TFQVATGDIA TEQVDVIVNS TARTFNRKSG VSRAILEGAG QAVESECAVL
     AAQPHRDFII TPGGCLKCKI IIHVPGGKDV RKTVTSVLEE CEQRKYTSVS LPAIGTGNLP
     EHWTDMNHQL FCMVQLEPGQ SEYNTIKDKF TRTCSSYAIE KIERIQNAFL WQSYQVKKRQ
     MDIKNDHKNN ERLLFHGTDA DSVPYVNQHG FNRSCAGKNA VSYGKGTYFA VDASYSAKDT
     YSKPDSNGRK HMYVVRVLTG VFTKGRAGLV TPPPKNPHNP TDLFDSVTNN TRSPKLFVVF
     FDNQAYPEYL ITFTA
//