ID   B7Z7D2_HUMAN            Unreviewed;       391 AA.
AC   B7Z7D2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   16-JAN-2019, entry version 79.
DE   SubName: Full=Lysosomal acid phosphatase {ECO:0000313|Ensembl:ENSP00000432205};
DE   SubName: Full=cDNA FLJ51131, highly similar to Lysosomal acid phosphatase {ECO:0000313|EMBL:BAH13568.1};
GN   Name=ACP2 {ECO:0000313|Ensembl:ENSP00000432205};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13568.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432205, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|EMBL:BAH13568.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAH13568.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000432205}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|SAAS:SAAS00793915}.
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DR   EMBL; AC018410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK301860; BAH13568.1; -; mRNA.
DR   RefSeq; NP_001289419.1; NM_001302490.1.
DR   UniGene; Hs.532492; -.
DR   jPOST; B7Z7D2; -.
DR   MaxQB; B7Z7D2; -.
DR   PRIDE; B7Z7D2; -.
DR   Ensembl; ENST00000527256; ENSP00000432205; ENSG00000134575.
DR   GeneID; 53; -.
DR   UCSC; uc010rhf.3; human.
DR   CTD; 53; -.
DR   EuPathDB; HostDB:ENSG00000134575.9; -.
DR   HGNC; HGNC:123; ACP2.
DR   OpenTargets; ENSG00000134575; -.
DR   GeneTree; ENSGT00940000158446; -.
DR   HOVERGEN; HBG002203; -.
DR   OrthoDB; 1221585at2759; -.
DR   ChiTaRS; ACP2; human.
DR   GenomeRNAi; 53; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134575; Expressed in 218 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; B7Z7D2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:B7Z7D2,
KW   ECO:0000213|MaxQB:B7Z7D2, ECO:0000213|PeptideAtlas:B7Z7D2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    391       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085666.
FT   TRANSMEM    349    372       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   391 AA;  44511 MW;  AAC4A82797E28E70 CRC64;
     MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLEG MLQHWELGQA LRQRYHGFLN
     TSYHRQEVYV RSTDFDRTLM SAEANLAGLF PPNGMQRFNP NISWQPIPVH TVPITEDRLL
     KFPLGPCPRY EQLQNETRQT PEYQNESSRN AQFLDMVANE TGLTDLTLET VWNVYDTLFC
     EQTHGLRLPP WASPQTMQRL SRLKDFSFRF LFGIYQQAEK ARLQGGVLLA QIRKNLTLMA
     TTSQLPKLLV YSAHDTTLVA LQMALDVYNG EQAPYASCHI FELYQEDSGN FSVEMYFRNE
     SDKAPWPLSL PGCPHRCPLQ DFLRLTEPVV PKDWQQECQL ASGPADTEVI VALAVCGSIL
     FLLIVLLLTV LFRMQAQPPG YRHVADGEDH A
//