ID   B7Z3U2_HUMAN            Unreviewed;       667 AA.
AC   B7Z3U2; K7EQM6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   13-FEB-2019, entry version 73.
DE   SubName: Full=Disks large homolog 4 {ECO:0000313|Ensembl:ENSP00000467897};
DE   SubName: Full=cDNA FLJ60612, highly similar to Discs large homolog 4 {ECO:0000313|EMBL:BAH12328.1};
GN   Name=DLG4 {ECO:0000313|Ensembl:ENSP00000467897};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH12328.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467897, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|EMBL:BAH12328.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAH12328.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000467897}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MAGUK family.
CC       {ECO:0000256|SAAS:SAAS00914726}.
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DR   EMBL; AC120057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK296357; BAH12328.1; -; mRNA.
DR   UniGene; Hs.463928; -.
DR   ProteinModelPortal; B7Z3U2; -.
DR   MaxQB; B7Z3U2; -.
DR   PeptideAtlas; B7Z3U2; -.
DR   PRIDE; B7Z3U2; -.
DR   Ensembl; ENST00000491753; ENSP00000467897; ENSG00000132535.
DR   UCSC; uc060aif.1; human.
DR   EuPathDB; HostDB:ENSG00000132535.18; -.
DR   HGNC; HGNC:2903; DLG4.
DR   OpenTargets; ENSG00000132535; -.
DR   eggNOG; KOG0708; Eukaryota.
DR   eggNOG; COG0194; LUCA.
DR   GeneTree; ENSGT00940000157956; -.
DR   HOVERGEN; HBG107814; -.
DR   ChiTaRS; DLG4; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000132535; Expressed in 146 organ(s), highest expression level in dorsolateral prefrontal cortex.
DR   ExpressionAtlas; B7Z3U2; baseline and differential.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR019583; PDZ_assoc.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 3.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B7Z3U2,
KW   ECO:0000213|PeptideAtlas:B7Z3U2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS00071823}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    667       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002866426.
FT   DOMAIN      108    195       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      203    290       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      356    437       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      471    541       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      577    667       Guanylate kinase-like.
FT                                {ECO:0000259|PROSITE:PS50052}.
SQ   SEQUENCE   667 AA;  73891 MW;  38902EC060BBE34F CRC64;
     MSQRPRAPRS ALWLLAPPLL RWAPPLLTVL HSDLFQALLD ILDYYEASLS ESQKYRYQDE
     DTPPLEHSPA HLPNQANSPP VIVNTDTLEA PGYELQVNGT EGEMEYEEIT LERGNSGLGF
     SIAGGTDNPH IGDDPSIFIT KIIPGGAAAQ DGRLRVNDSI LFVNEVDVRE VTHSAAVEAL
     KEAGSIVRLY VMRRKPPAEK VMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG
     GAAHKDGRLQ IGDKILAVNS VGLEDVMHED AVAALKNTYD VVYLKVAKPS NAYLSDSYAP
     PDITTSYSQH LDNEISHSSY LGTDYPTAMT PTSPRRYSPV AKDLLGEEDI PREPRRIVIH
     RGSTGLGFNI VGGEDGEGIF ISFILAGGPA DLSGELRKGD QILSVNGVDL RNASHEQAAI
     ALKNAGQTVT IIAQYKPEEY SRFEAKIHDL REQLMNSSLG SGTASLRSNP KRGFYIRALF
     DYDKTKDCGF LSQALSFRFG DVLHVIDASD EEWWQARRVH SDSETDDIGF IPSKRRVERR
     EWSRLKAKDW GSSSGSQGRE DSVLSYETVT QMEVHYARPI IILGPTKDRA NDDLLSEFPD
     KFGSCVPHTT RPKREYEIDG RDYHFVSSRE KMEKDIQAHK FIEAGQYNSH LYGTSVQSVR
     EVAEQRD
//