ID   B7Z2C8_HUMAN            Unreviewed;       531 AA.
AC   B7Z2C8;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   12-SEP-2018, entry version 85.
DE   SubName: Full=F-box/WD repeat-containing protein 7 {ECO:0000313|Ensembl:ENSP00000377528};
DE   SubName: Full=cDNA FLJ55681, highly similar to F-box/WD repeat protein 7 {ECO:0000313|EMBL:BAH11814.1};
GN   Name=FBXW7 {ECO:0000313|Ensembl:ENSP00000377528};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11814.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000377528, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|EMBL:BAH11814.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Amygdala {ECO:0000313|EMBL:BAH11814.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000377528}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC023424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC080078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK294568; BAH11814.1; -; mRNA.
DR   UniGene; Hs.561245; -.
DR   UniGene; Hs.717081; -.
DR   MaxQB; B7Z2C8; -.
DR   PeptideAtlas; B7Z2C8; -.
DR   PRIDE; B7Z2C8; -.
DR   Ensembl; ENST00000393956; ENSP00000377528; ENSG00000109670.
DR   UCSC; uc011cih.3; human.
DR   EuPathDB; HostDB:ENSG00000109670.13; -.
DR   HGNC; HGNC:16712; FBXW7.
DR   OpenTargets; ENSG00000109670; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   eggNOG; ENOG410XRWX; LUCA.
DR   HOGENOM; HOG000236264; -.
DR   HOVERGEN; HBG051596; -.
DR   ChiTaRS; FBXW7; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000109670; Expressed in 239 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; B7Z2C8; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B7Z2C8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    531       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085663.
FT   DOMAIN      102    148       F-box. {ECO:0000259|PROSITE:PS50181}.
FT   DOMAIN      200    483       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
FT   REPEAT      215    240       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      241    280       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      281    320       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      321    360       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      361    400       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      401    440       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      444    483       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
SQ   SEQUENCE   531 AA;  59724 MW;  11346DF035AC0F4A CRC64;
     MLFFKCISLL LIWLIPGQST TGLVPCSATP TTFGDLRAAN GQGQQRRRIT SVQPPTGLQE
     WLKMFQSWSG PEKLLALDEL IDSCEPTQVK HMMQVIEPQF QRDFISLLPK ELALYVLSFL
     EPKDLLQAAQ TCRYWRILAE DNLLWREKCK EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI
     RQHRIDTNWR RGELKSPKVL KGHDDHVITC LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT
     LVGHTGGVWS SQMRDNIIIS GSTDRTLKVW NAETGECIHT LYGHTSTVRC MHLHEKRVVS
     GSRDATLRVW DIETGQCLHV LMGHVAAVRC VQYDGRRVVS GAYDFMVKVW DPETETCLHT
     LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW DVETGNCIHT LTGHQSLTSG MELKDNILVS
     GNADSTVKIW DIKTGQCLQT LQGPNKHQSA VTCLQFNKNF VITSSDDGTV KLWDLKTGEF
     IRNLVTLESG GSGGVVWRIR ASNTKLVCAV GSRNGTEETK LLVLDFDVDM K
//