ID   B7WNN4_HUMAN            Unreviewed;       134 AA.
AC   B7WNN4;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=NAD-dependent protein deacetylase sirtuin-3, mitochondrial {ECO:0000313|Ensembl:ENSP00000434747};
GN   Name=SIRT3 {ECO:0000313|Ensembl:ENSP00000434747};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434747, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434747, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434747}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC136475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B7WNN4; -.
DR   jPOST; B7WNN4; -.
DR   MaxQB; B7WNN4; -.
DR   PeptideAtlas; B7WNN4; -.
DR   PRIDE; B7WNN4; -.
DR   Ensembl; ENST00000529937; ENSP00000434747; ENSG00000142082.
DR   UCSC; uc057xcy.1; human.
DR   EuPathDB; HostDB:ENSG00000142082.14; -.
DR   HGNC; HGNC:14931; SIRT3.
DR   OpenTargets; ENSG00000142082; -.
DR   eggNOG; KOG2682; Eukaryota.
DR   eggNOG; COG0846; LUCA.
DR   GeneTree; ENSGT00940000159464; -.
DR   HOGENOM; HOG000081755; -.
DR   ChiTaRS; SIRT3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000142082; Expressed in 214 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; B7WNN4; baseline and differential.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B7WNN4,
KW   ECO:0000213|PeptideAtlas:B7WNN4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    134       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002863037.
FT   DOMAIN        1    134       Deacetylase sirtuin-type.
FT                                {ECO:0000259|PROSITE:PS50305}.
SQ   SEQUENCE   134 AA;  14493 MW;  3CF8D1148326A1B2 CRC64;
     MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDADVMA DRVPRCPVCT
     GVVKPDIVFF GEPLPQRFLL HVVDFPMADL LLILGTSLEV CQQACAGRRL EGRGREGYRS
     HLMGPSRAGA TLGR
//