ID   B6ZDM2_HUMAN            Unreviewed;       938 AA.
AC   B6ZDM2;
DT   20-JAN-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 2.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Pecanex-like protein 4 {ECO:0000313|Ensembl:ENSP00000317396};
GN   Name=PCNX4 {ECO:0000313|Ensembl:ENSP00000317396};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000317396, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000317396, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000317396}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL157911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL163853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_071940.4; NM_022495.5.
DR   UniGene; Hs.509499; -.
DR   ProteinModelPortal; B6ZDM2; -.
DR   jPOST; B6ZDM2; -.
DR   PeptideAtlas; B6ZDM2; -.
DR   PRIDE; B6ZDM2; -.
DR   DNASU; 64430; -.
DR   Ensembl; ENST00000317623; ENSP00000317396; ENSG00000126773.
DR   GeneID; 64430; -.
DR   UCSC; uc001xer.5; human.
DR   CTD; 64430; -.
DR   EuPathDB; HostDB:ENSG00000126773.12; -.
DR   HGNC; HGNC:20349; PCNX4.
DR   OpenTargets; ENSG00000126773; -.
DR   PharmGKB; PA134919147; -.
DR   eggNOG; ENOG410INC2; Eukaryota.
DR   eggNOG; ENOG410XRMG; LUCA.
DR   GeneTree; ENSGT00940000156899; -.
DR   HOGENOM; HOG000067757; -.
DR   HOVERGEN; HBG056012; -.
DR   OrthoDB; 1243516at2759; -.
DR   TreeFam; TF313570; -.
DR   ChiTaRS; PCNX4; human.
DR   GenomeRNAi; 64430; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000126773; Expressed in 213 organ(s), highest expression level in kidney.
DR   ExpressionAtlas; B6ZDM2; baseline and differential.
DR   Genevisible; B6ZDM2; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039797; Pecanex.
DR   InterPro; IPR007735; Pecanex_C.
DR   PANTHER; PTHR12372; PTHR12372; 1.
DR   Pfam; PF05041; Pecanex_C; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B6ZDM2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    938       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002850649.
FT   TRANSMEM     12     36       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     80     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    143       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    155    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    300    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    402    424       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      776    930       Pecanex_C. {ECO:0000259|Pfam:PF05041}.
SQ   SEQUENCE   938 AA;  106350 MW;  3D0507C407E2E259 CRC64;
     MPALEHMNQI LHILFVFLPF LWALGTLPPP DALLLWAMEQ VLEFGLGGSS MSTHLRLLVM
     FIMSAGTAIA SYFIPSTVGV VLFMTGFGFL LSLNLSDMGH KIGTKSKDLP SGPEKHFSWK
     ECLFYIIILV LALLETSLLH HFAGFSQISK SNSQAIVGYG LMILLIILWI LREIQSVYII
     GIFRNPFYPK DVQTVTVFFE KQTRLMKIGI VRRILLTLVS PFAMIAFLSL DSSLQGLHSV
     SVCIGFTRAF RMVWQNTENA LLETVIVSTV HLISSTDIWW NRSLDTGLRL LLVGIIRDRL
     IQFISKLQFA VTVLLTSWTE KKQRRKTTAT LCILNIVFSP FVLVIIVFST LLSSPLLPLF
     TLPVFLVGFP RPIQSWPGAA GTTACVCADT VYYYQMVPRL TAVLQTAMAA GSLGLLLPGS
     HYLGRFQDRL MWIMILECGY TYCSINIKGL ELQETSCHTA EARRVDEVFE DAFEQEYTRV
     CSLNEHFGNV LTPCTVLPVK LYSDARNVLS GIIDSHENLK EFKGDLIKVL VWILVQYCSK
     RPGMKENVHN TENKGKAPLM LPALNTLPPP KSPEDIDSLN SETFNDWSDD NIFDDEPTIK
     KVIEEKHQLK DLPGTNLFIP GSVESQRVGD HSTGTVPEND LYKAVLLGYP AVDKGKQEDM
     PYIPLMEFSC SHSHLVCLPA EWRTSCMPSS KMKEMSSLFP EDWYQFVLRQ LECYHSEEKA
     SNVLEEIAKD KVLKDFYVHT VMTCYFSLFG IDNMAPSPGH ILRVYGGVLP WSVALDWLTE
     KPELFQLALK AFRYTLKLMI DKASLGPIED FRELIKYLEE YERDWYIGLV SDEKWKEAIL
     QEKPYLFSLG YDSNMGIYTG RVLSLQELLI QVGKLNPEAV RGQWANLSWE LLYATNDDEE
     RYSIQAHPLL LRNLTVQAAE PPLGYPIYSS KPLHIHLY
//