ID   ERVV2_HUMAN             Reviewed;         535 AA.
AC   B6SEH9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   RecName: Full=Endogenous retrovirus group V member 2 Env polyprotein;
DE   AltName: Full=HERV-V_19q13.41 provirus ancestral Env polyprotein 2;
DE   Flags: Precursor;
GN   Name=ERVV-2; Synonyms=ENVV2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=18826608; DOI=10.1186/1471-2148-8-266;
RA   Kjeldbjerg A.L., Villesen P., Aagaard L., Pedersen F.S.;
RT   "Gene conversion and purifying selection of a placenta-specific ERV-V
RT   envelope gene during simian evolution.";
RL   BMC Evol. Biol. 8:266-266(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta.
CC       {ECO:0000269|PubMed:18826608}.
CC   -!- SIMILARITY: Belongs to the gamma type-C retroviral envelope
CC       protein family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; EU853143; ACI62854.1; -; Genomic_DNA.
DR   EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59420.1; -.
DR   RefSeq; NP_001177984.1; NM_001191055.1.
DR   UniGene; Hs.420445; -.
DR   ProteinModelPortal; B6SEH9; -.
DR   SMR; B6SEH9; -.
DR   iPTMnet; B6SEH9; -.
DR   PhosphoSitePlus; B6SEH9; -.
DR   BioMuta; ERVV-2; -.
DR   jPOST; B6SEH9; -.
DR   PaxDb; B6SEH9; -.
DR   PRIDE; B6SEH9; -.
DR   ProteomicsDB; 6249; -.
DR   Ensembl; ENST00000601417; ENSP00000472919; ENSG00000268964.
DR   GeneID; 100271846; -.
DR   KEGG; hsa:100271846; -.
DR   CTD; 100271846; -.
DR   DisGeNET; 100271846; -.
DR   EuPathDB; HostDB:ENSG00000268964.1; -.
DR   GeneCards; ERVV-2; -.
DR   HGNC; HGNC:39051; ERVV-2.
DR   neXtProt; NX_B6SEH9; -.
DR   eggNOG; ENOG410J8IS; Eukaryota.
DR   eggNOG; ENOG4111C12; LUCA.
DR   GeneTree; ENSGT00940000164101; -.
DR   HOVERGEN; HBG105654; -.
DR   InParanoid; B6SEH9; -.
DR   OMA; LFLFGPC; -.
DR   OrthoDB; 389221at2759; -.
DR   ChiTaRS; ERVV-2; human.
DR   GenomeRNAi; 100271846; -.
DR   PRO; PR:B6SEH9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000268964; Expressed in 4 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; B6SEH9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018154; TLV/ENV_coat_polyprotein.
DR   PANTHER; PTHR10424; PTHR10424; 1.
DR   Pfam; PF00429; TLV_coat; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; ERV; Glycoprotein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix; Transposable element.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    535       Endogenous retrovirus group V member 2
FT                                Env polyprotein.
FT                                /FTId=PRO_0000411001.
FT   TOPO_DOM     22    321       Extracellular. {ECO:0000255}.
FT   TRANSMEM    322    342       Helical. {ECO:0000255}.
FT   TOPO_DOM    343    456       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    457    477       Helical. {ECO:0000255}.
FT   TOPO_DOM    478    535       Extracellular. {ECO:0000255}.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   535 AA;  59317 MW;  42A12AA10BC6D3A7 CRC64;
     MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
     LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
     LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
     NRCAAWEGKE LITWRVLYSL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
     DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
     LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
     KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA VINKSCCVYV NNSGAIEEDI
     KKIYDEATWL HDFGKGGASA RAIWEAVKSA LPSLNWFVPL LGPATVILLL FLFGPCFFNL
     LIKCVSSRIK QFHMKSPQME RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL
//