ID   ERVV1_HUMAN             Reviewed;         477 AA.
AC   B6SEH8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   RecName: Full=Endogenous retrovirus group V member 1 Env polyprotein;
DE   AltName: Full=HERV-V_19q13.41 provirus ancestral Env polyprotein 1;
DE   Flags: Precursor;
GN   Name=ERVV-1; Synonyms=ENVV1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=18826608; DOI=10.1186/1471-2148-8-266;
RA   Kjeldbjerg A.L., Villesen P., Aagaard L., Pedersen F.S.;
RT   "Gene conversion and purifying selection of a placenta-specific ERV-V
RT   envelope gene during simian evolution.";
RL   BMC Evol. Biol. 8:266-266(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta.
CC       {ECO:0000269|PubMed:18826608}.
CC   -!- SIMILARITY: Belongs to the gamma type-C retroviral envelope
CC       protein family. {ECO:0000305}.
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DR   EMBL; EU853142; ACI62853.1; -; Genomic_DNA.
DR   EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59419.1; -.
DR   RefSeq; NP_689686.2; NM_152473.2.
DR   UniGene; Hs.44329; -.
DR   ProteinModelPortal; B6SEH8; -.
DR   SMR; B6SEH8; -.
DR   BioGrid; 127071; 1.
DR   STRING; 9606.ENSP00000473153; -.
DR   BioMuta; ERVV-1; -.
DR   PaxDb; B6SEH8; -.
DR   PRIDE; B6SEH8; -.
DR   ProteomicsDB; 6248; -.
DR   Ensembl; ENST00000602168; ENSP00000473153; ENSG00000269526.
DR   GeneID; 147664; -.
DR   KEGG; hsa:147664; -.
DR   CTD; 147664; -.
DR   DisGeNET; 147664; -.
DR   EuPathDB; HostDB:ENSG00000269526.1; -.
DR   GeneCards; ERVV-1; -.
DR   H-InvDB; HIX0019088; -.
DR   HGNC; HGNC:26501; ERVV-1.
DR   neXtProt; NX_B6SEH8; -.
DR   eggNOG; ENOG410J8IS; Eukaryota.
DR   eggNOG; ENOG4111C12; LUCA.
DR   GeneTree; ENSGT00940000164101; -.
DR   HOVERGEN; HBG105654; -.
DR   InParanoid; B6SEH8; -.
DR   OMA; SHCWICH; -.
DR   OrthoDB; 389221at2759; -.
DR   GenomeRNAi; 147664; -.
DR   PRO; PR:B6SEH8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000269526; Expressed in 25 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; B6SEH8; baseline and differential.
DR   Genevisible; B6SEH8; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018154; TLV/ENV_coat_polyprotein.
DR   PANTHER; PTHR10424; PTHR10424; 1.
DR   Pfam; PF00429; TLV_coat; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; ERV; Glycoprotein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix; Transposable element.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    477       Endogenous retrovirus group V member 1
FT                                Env polyprotein.
FT                                /FTId=PRO_0000411000.
FT   TOPO_DOM     22    321       Extracellular. {ECO:0000255}.
FT   TRANSMEM    322    342       Helical. {ECO:0000255}.
FT   TOPO_DOM    343    477       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   477 AA;  52557 MW;  90CD27A4D7B55129 CRC64;
     MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
     LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
     LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
     NRCAAWEGKE LITWRVLYLL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
     DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
     LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
     KSTRDSISKL KASIDSLANV VMNNRLALDY LLAEQGGVCA VISKSCCIYV NNSGAIEEDI
     KKIYDEVTWL HNFGKGDSAG SIWEAVKSAL PSLTWFVPLL GPAALNSLLS PLWPLSL
//