ID TARM1_HUMAN Reviewed; 271 AA. AC B6A8C7; B4DWY4; DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 1. DT 16-JAN-2019, entry version 76. DE RecName: Full=T-cell-interacting, activating receptor on myeloid cells protein 1; DE AltName: Full=OSCAR-like transcript-2 protein; DE Short=OLT-2; DE Flags: Precursor; GN Name=TARM1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Bone marrow; RA Barrow A.D., de Bono B., Trowsdale J.; RT "OSCAR-like transcript-2 (OLT-2) mRNA."; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [4] RP FUNCTION, INTERACTION WITH FCER1G, SUBCELLULAR LOCATION, TISSUE RP SPECIFICITY, AND GLYCOSYLATION. RX PubMed=26311901; DOI=10.4049/jimmunol.1401847; RA Radjabova V., Mastroeni P., Skjoedt K., Zaccone P., de Bono B., RA Goodall J.C., Chilvers E.R., Juss J.K., Jones D.C., Trowsdale J., RA Barrow A.D.; RT "TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor RT that costimulates proinflammatory cytokine secretion by macrophages RT and neutrophils."; RL J. Immunol. 195:3149-3159(2015). CC -!- FUNCTION: May act as receptor (By similarity). Negatively CC regulates TCR-mediated CD4(+) T cell proliferation and activation, CC possibly by binding an unknown ligand on the T cell surface CC (PubMed:26311901). Enhances Toll-like receptor-mediated production CC of pro-inflammatory cytokines by macrophages and neutrophils (By CC similarity). {ECO:0000250|UniProtKB:B6A8R8, CC ECO:0000269|PubMed:26311901}. CC -!- SUBUNIT: Interacts with Fc receptor gamma chain FCER1G. CC {ECO:0000269|PubMed:26311901}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26311901}; CC Single-pass type I membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=B6A8C7-1; Sequence=Displayed; CC Note=No experimental confirmation available.; CC Name=2; CC IsoId=B6A8C7-2; Sequence=VSP_039225; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Expressed in fetal and adult liver, lung, CC testis, thymus and spleen. Expressed in blood neutrophils. CC {ECO:0000269|PubMed:26311901}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:26311901}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; DQ479398; ABF19808.1; -; mRNA. DR EMBL; AK301730; BAG63196.1; -; mRNA. DR EMBL; AC012314; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS46173.1; -. [B6A8C7-1] DR CCDS; CCDS82395.1; -. [B6A8C7-2] DR RefSeq; NP_001129158.2; NM_001135686.2. DR RefSeq; NP_001317579.1; NM_001330650.1. DR UniGene; Hs.694674; -. DR ProteinModelPortal; B6A8C7; -. DR SMR; B6A8C7; -. DR iPTMnet; B6A8C7; -. DR PhosphoSitePlus; B6A8C7; -. DR BioMuta; TARM1; -. DR PaxDb; B6A8C7; -. DR PRIDE; B6A8C7; -. DR ProteomicsDB; 6241; -. DR ProteomicsDB; 6242; -. [B6A8C7-2] DR Ensembl; ENST00000432826; ENSP00000439454; ENSG00000248385. DR Ensembl; ENST00000611088; ENSP00000479824; ENSG00000276145. [B6A8C7-1] DR Ensembl; ENST00000611419; ENSP00000478234; ENSG00000275806. [B6A8C7-1] DR Ensembl; ENST00000612678; ENSP00000482624; ENSG00000275123. [B6A8C7-1] DR Ensembl; ENST00000614463; ENSP00000480049; ENSG00000276355. [B6A8C7-1] DR Ensembl; ENST00000615726; ENSP00000479185; ENSG00000275384. [B6A8C7-1] DR Ensembl; ENST00000619320; ENSP00000479062; ENSG00000276604. [B6A8C7-1] DR Ensembl; ENST00000620140; ENSP00000477830; ENSG00000276355. [B6A8C7-2] DR Ensembl; ENST00000620398; ENSP00000479374; ENSG00000273875. [B6A8C7-1] DR Ensembl; ENST00000620707; ENSP00000480377; ENSG00000277178. [B6A8C7-1] DR Ensembl; ENST00000622245; ENSP00000478822; ENSG00000274889. [B6A8C7-1] DR GeneID; 441864; -. DR KEGG; hsa:441864; -. DR UCSC; uc010yei.1; human. [B6A8C7-1] DR CTD; 441864; -. DR EuPathDB; HostDB:ENSG00000248385.7; -. DR GeneCards; TARM1; -. DR HGNC; HGNC:37250; TARM1. DR HPA; HPA051022; -. DR HPA; HPA054401; -. DR neXtProt; NX_B6A8C7; -. DR PharmGKB; PA165394443; -. DR eggNOG; ENOG410J9W1; Eukaryota. DR eggNOG; ENOG411166F; LUCA. DR HOGENOM; HOG000234395; -. DR HOVERGEN; HBG105594; -. DR InParanoid; B6A8C7; -. DR OrthoDB; 1327293at2759; -. DR PhylomeDB; B6A8C7; -. DR TreeFam; TF336644; -. DR Reactome; R-HSA-6798695; Neutrophil degranulation. DR GenomeRNAi; 441864; -. DR PRO; PR:B6A8C7; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000248385; Expressed in 9 organ(s), highest expression level in blood. DR ExpressionAtlas; B6A8C7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome. DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome. DR GO; GO:0034987; F:immunoglobulin receptor binding; IPI:UniProtKB. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:2000515; P:negative regulation of CD4-positive, alpha-beta T cell activation; IDA:UniProtKB. DR GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR Pfam; PF13895; Ig_2; 1. DR SMART; SM00409; IG; 2. DR SUPFAM; SSF48726; SSF48726; 2. PE 1: Evidence at protein level; KW Adaptive immunity; Alternative splicing; Cell membrane; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; KW Immunoglobulin domain; Innate immunity; Membrane; Polymorphism; KW Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 16 {ECO:0000255}. FT CHAIN 17 271 T-cell-interacting, activating receptor FT on myeloid cells protein 1. FT /FTId=PRO_0000394231. FT TOPO_DOM 17 236 Extracellular. {ECO:0000255}. FT TRANSMEM 237 257 Helical. {ECO:0000255}. FT TOPO_DOM 258 271 Cytoplasmic. {ECO:0000255}. FT DOMAIN 27 113 Ig-like C2-type 1. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT DOMAIN 126 212 Ig-like C2-type 2. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT CARBOHYD 44 44 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 49 97 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 146 196 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 1 12 MIPKLLSLLCFR -> MKERKKKERKERKRKKERNG (in FT isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_039225. FT VARIANT 37 37 S -> P (in dbSNP:rs17305269). FT /FTId=VAR_063151. FT VARIANT 111 111 R -> H (in dbSNP:rs80087697). FT /FTId=VAR_063152. FT VARIANT 258 258 R -> W (in dbSNP:rs77768804). FT /FTId=VAR_063153. SQ SEQUENCE 271 AA; 29474 MW; B1E2B17A1C657060 CRC64; MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW TPARGVSFVL RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY RKASPHILSQ RSDVLLLLVT GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID FSLVDVTAGD AGNYSCMYYQ TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA AVIVVIMGAF LVEAWYSRNV SPGESEAFKP E //