ID   B5MDP7_HUMAN            Unreviewed;       808 AA.
AC   B5MDP7;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   05-DEC-2018, entry version 80.
DE   SubName: Full=Papilin {ECO:0000313|Ensembl:ENSP00000216658};
GN   Name=PAPLN {ECO:0000313|Ensembl:ENSP00000216658};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000216658, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000216658, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000216658}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC004846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B5MDP7; -.
DR   PeptideAtlas; B5MDP7; -.
DR   PRIDE; B5MDP7; -.
DR   Ensembl; ENST00000216658; ENSP00000216658; ENSG00000100767.
DR   UCSC; uc059dbw.1; human.
DR   EuPathDB; HostDB:ENSG00000100767.15; -.
DR   HGNC; HGNC:19262; PAPLN.
DR   OpenTargets; ENSG00000100767; -.
DR   eggNOG; KOG3510; Eukaryota.
DR   eggNOG; KOG4597; Eukaryota.
DR   eggNOG; ENOG410XQNP; LUCA.
DR   GeneTree; ENSGT00940000156891; -.
DR   HOGENOM; HOG000060119; -.
DR   HOVERGEN; HBG108281; -.
DR   ChiTaRS; PAPLN; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100767; Expressed in 176 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; B5MDP7; baseline and differential.
DR   Gene3D; 2.20.100.10; -; 5.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B5MDP7,
KW   ECO:0000213|PeptideAtlas:B5MDP7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    808       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002834836.
FT   DOMAIN      184    298       ADAM_spacer1. {ECO:0000259|Pfam:PF05986}.
SQ   SEQUENCE   808 AA;  87275 MW;  EB5F9785145CBF0B CRC64;
     MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG
     GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC
     IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT
     TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI
     EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR
     RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC
     PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN
     LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC
     PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL
     PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG
     THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ
     SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR
     GSQFGCCYDN VATAAGPLGE GCVGQPSHGL AWQVWSPRWC RQPWGSWCGS PAQTTLPRNP
     RLPGRKMASP SPLTGVCDGP PTSSDRCV
//