ID   B5MC71_HUMAN            Unreviewed;        71 AA.
AC   B5MC71;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|Ensembl:ENSP00000386056};
GN   Name=ADAM10 {ECO:0000313|Ensembl:ENSP00000386056};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386056, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386056, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386056}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B5MC71; -.
DR   EPD; B5MC71; -.
DR   jPOST; B5MC71; -.
DR   PeptideAtlas; B5MC71; -.
DR   PRIDE; B5MC71; -.
DR   Ensembl; ENST00000402627; ENSP00000386056; ENSG00000137845.
DR   UCSC; uc059jro.1; human.
DR   EuPathDB; HostDB:ENSG00000137845.14; -.
DR   HGNC; HGNC:188; ADAM10.
DR   OpenTargets; ENSG00000137845; -.
DR   eggNOG; KOG3658; Eukaryota.
DR   eggNOG; ENOG410XQWB; LUCA.
DR   GeneTree; ENSGT00940000160579; -.
DR   HOGENOM; HOG000074077; -.
DR   ChiTaRS; ADAM10; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137845; Expressed in 242 organ(s), highest expression level in testis.
DR   ExpressionAtlas; B5MC71; baseline and differential.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B5MC71,
KW   ECO:0000213|PeptideAtlas:B5MC71};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19     71       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002836644.
SQ   SEQUENCE   71 AA;  7489 MW;  1B97CE8D22A5ADBA CRC64;
     MVLLRVLILL LSWAAGMGDR DFDDGVLGLA WVGAPSGSSG GICEKSKLYS DVPTMGKLHS
     KEKPIKSSSP N
//