ID B5MBX2_HUMAN Unreviewed; 423 AA. AC B5MBX2; DT 14-OCT-2008, integrated into UniProtKB/TrEMBL. DT 14-OCT-2008, sequence version 1. DT 16-JAN-2019, entry version 58. DE SubName: Full=Transcobalamin-2 {ECO:0000313|Ensembl:ENSP00000385914}; GN Name=TCN2 {ECO:0000313|Ensembl:ENSP00000385914}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385914, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000385914, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., RA Khan A.S., Lane L., Tilahun Y., Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [2] {ECO:0000313|Ensembl:ENSP00000385914} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005006; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; B5MBX2; -. DR jPOST; B5MBX2; -. DR PeptideAtlas; B5MBX2; -. DR PRIDE; B5MBX2; -. DR Ensembl; ENST00000405742; ENSP00000385914; ENSG00000185339. DR UCSC; uc062dfb.1; human. DR EuPathDB; HostDB:ENSG00000185339.8; -. DR HGNC; HGNC:11653; TCN2. DR OpenTargets; ENSG00000185339; -. DR eggNOG; ENOG410IDZK; Eukaryota. DR eggNOG; ENOG410XSU1; LUCA. DR GeneTree; ENSGT00530000063370; -. DR HOGENOM; HOG000074060; -. DR HOVERGEN; HBG001328; -. DR ChiTaRS; TCN2; human. DR Proteomes; UP000005640; Chromosome 22. DR Bgee; ENSG00000185339; Expressed in 136 organ(s), highest expression level in esophagus. DR ExpressionAtlas; B5MBX2; baseline and differential. DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro. DR GO; GO:0015889; P:cobalamin transport; IEA:InterPro. DR InterPro; IPR002157; Cbl-bd_prot. DR InterPro; IPR027954; DUF4430. DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase. DR Pfam; PF01122; Cobalamin_bind; 1. DR Pfam; PF14478; DUF4430; 1. DR SUPFAM; SSF48239; SSF48239; 1. DR PROSITE; PS00468; COBALAMIN_BINDING; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:B5MBX2, KW ECO:0000213|PeptideAtlas:B5MBX2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 423 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002836721. FT DOMAIN 348 420 DUF4430. {ECO:0000259|Pfam:PF14478}. SQ SEQUENCE 423 AA; 47143 MW; 3CD7A5799F82E2B4 CRC64; MRHLGAFLFL LGVLGALTEM CEIPEMDSHL VEKLGQHLLP WMDRLSLEHL NPSIYVGLRL SSLQAGTKED LYLHSLKLGY QQCLLGEDDG DCQGKPSMGQ LALYLLALRA NCEFVRGHKG DRLVSQLKWF LEDEKRAIGH DHKGHPHTSY YQYGLGILAL CLHQKRVHDS VVDKLLYAVE PFHQGHHSVD TAAMAGLAFT CLKRSNFNPG RRQRITMAIR TVREEILKAQ TPEGHFGNVY STPLALQFLM TSPMRGAELG TACLKARVAL LASLQDGAFQ NALMISQLLP VLNHKTYIDL IFPDCLAPRV MLEPAAETIP QTQEIISVTL QVLSLLPPYR QSISVLAGST VEDVLKKAHE LGGFTYETQA SLSGPYLTSV MGKAAGEREF WQLLRDPNTP LLQGIADYRP KDGETIELRL VSW //