ID   B5A982_HUMAN            Unreviewed;       128 AA.
AC   B5A982;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   10-OCT-2018, entry version 76.
DE   SubName: Full=Advanced glycosylation end product-specific receptor {ECO:0000313|Ensembl:ENSP00000445389};
DE   SubName: Full=Advanced glycosylation end products transcript variant {ECO:0000313|EMBL:ACL80027.1};
DE   SubName: Full=Soluble RAGE variant 5 {ECO:0000313|EMBL:ACF47656.1};
GN   Name=AGER {ECO:0000313|EMBL:ACL80027.1,
GN   ECO:0000313|Ensembl:ENSP00000445389};
GN   Synonyms=RAGE {ECO:0000313|EMBL:ACF47656.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACF47656.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000445389, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:ACF47656.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18593464; DOI=10.1186/ar2447;
RA   Jin P., Zhang J., Sumariwalla P.F., Ni I., Jorgensen B., Crawford D.,
RA   Phillips S., Feldmann M., Shepard H.M., Paleolog E.M.;
RT   "Novel splice variants derived from the receptor tyrosine kinase
RT   superfamily are potential therapeutics for rheumatoid arthritis.";
RL   Arthritis Res. Ther. 10:R73-R73(2008).
RN   [3] {ECO:0000313|EMBL:ACL80027.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rouhiainen A., Kuja-Panula J., Rauvala H.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000445389}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSP00000446582}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AL662830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL662884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL845464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX284686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX927239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU826620; ACF47656.1; -; mRNA.
DR   EMBL; FJ545655; ACL80027.1; -; mRNA.
DR   UniGene; Hs.534342; -.
DR   PRIDE; B5A982; -.
DR   Ensembl; ENST00000538695; ENSP00000445389; ENSG00000204305.
DR   Ensembl; ENST00000548959; ENSP00000447095; ENSG00000234729.
DR   Ensembl; ENST00000550854; ENSP00000450205; ENSG00000206320.
DR   Ensembl; ENST00000551684; ENSP00000448028; ENSG00000237405.
DR   Ensembl; ENST00000553014; ENSP00000446582; ENSG00000229058.
DR   UCSC; uc063nqa.1; human.
DR   EuPathDB; HostDB:ENSG00000204305.13; -.
DR   HGNC; HGNC:320; AGER.
DR   OpenTargets; ENSG00000204305; -.
DR   eggNOG; ENOG410IVT2; Eukaryota.
DR   eggNOG; ENOG4111C4I; LUCA.
DR   GeneTree; ENSGT00890000139566; -.
DR   HOVERGEN; HBG084276; -.
DR   ChiTaRS; AGER; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000204305; Expressed in 111 organ(s), highest expression level in right lung.
DR   ExpressionAtlas; B5A982; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B5A982,
KW   ECO:0000213|PeptideAtlas:B5A982};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    128       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014567711.
FT   DOMAIN       31    116       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   128 AA;  14017 MW;  687A511FB6879DE8 CRC64;
     MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA
     WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQF
     ENLHNYSL
//