ID   B5A977_HUMAN            Unreviewed;       155 AA.
AC   B5A977;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   05-DEC-2018, entry version 79.
DE   SubName: Full=Soluble TNFR1B variant 1 {ECO:0000313|EMBL:ACF47651.1};
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 1B {ECO:0000313|Ensembl:ENSP00000440425};
GN   Name=TNFRSF1B {ECO:0000313|Ensembl:ENSP00000440425};
GN   Synonyms=TNFR1B {ECO:0000313|EMBL:ACF47651.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACF47651.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440425, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|EMBL:ACF47651.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18593464; DOI=10.1186/ar2447;
RA   Jin P., Zhang J., Sumariwalla P.F., Ni I., Jorgensen B., Crawford D.,
RA   Phillips S., Feldmann M., Shepard H.M., Paleolog E.M.;
RT   "Novel splice variants derived from the receptor tyrosine kinase
RT   superfamily are potential therapeutics for rheumatoid arthritis.";
RL   Arthritis Res. Ther. 10:R73-R73(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000440425}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AL031276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL357835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU826615; ACF47651.1; -; mRNA.
DR   UniGene; Hs.256278; -.
DR   PRIDE; B5A977; -.
DR   Ensembl; ENST00000536782; ENSP00000440425; ENSG00000028137.
DR   UCSC; uc057cji.1; human.
DR   EuPathDB; HostDB:ENSG00000028137.16; -.
DR   HGNC; HGNC:11917; TNFRSF1B.
DR   OpenTargets; ENSG00000028137; -.
DR   eggNOG; ENOG410IJ06; Eukaryota.
DR   eggNOG; ENOG410YPQW; LUCA.
DR   GeneTree; ENSGT00940000161800; -.
DR   HOGENOM; HOG000132845; -.
DR   ChiTaRS; TNFRSF1B; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000028137; Expressed in 210 organ(s), highest expression level in blood.
DR   ExpressionAtlas; B5A977; baseline and differential.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Proteomics identification {ECO:0000213|MaxQB:B5A977,
KW   ECO:0000213|PeptideAtlas:B5A977};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    155       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014567713.
FT   REPEAT       39     75       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN       39     75       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT       77    118       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN       77    118       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   DISULFID     54     67       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     57     75       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     78     93       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID    100    118       {ECO:0000256|PROSITE-ProRule:PRU00206}.
SQ   SEQUENCE   155 AA;  17015 MW;  3C1B33890D3E340E CRC64;
     MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG
     QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC
     RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPDLS
//