ID   B5A958_HUMAN            Unreviewed;       228 AA.
AC   B5A958;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 73.
DE   SubName: Full=Fibroblast growth factor receptor 1 {ECO:0000313|Ensembl:ENSP00000484553};
DE   SubName: Full=Soluble FGFR1 variant 1 {ECO:0000313|EMBL:ACF47632.1};
GN   Name=FGFR1 {ECO:0000313|EMBL:ACF47632.1,
GN   ECO:0000313|Ensembl:ENSP00000484553};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACF47632.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484553, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|EMBL:ACF47632.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18593464; DOI=10.1186/ar2447;
RA   Jin P., Zhang J., Sumariwalla P.F., Ni I., Jorgensen B., Crawford D.,
RA   Phillips S., Feldmann M., Shepard H.M., Paleolog E.M.;
RT   "Novel splice variants derived from the receptor tyrosine kinase
RT   superfamily are potential therapeutics for rheumatoid arthritis.";
RL   Arthritis Res. Ther. 10:R73-R73(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000484553}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC087623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU826596; ACF47632.1; -; mRNA.
DR   UniGene; Hs.264887; -.
DR   SMR; B5A958; -.
DR   jPOST; B5A958; -.
DR   PRIDE; B5A958; -.
DR   Ensembl; ENST00000619564; ENSP00000484553; ENSG00000077782.
DR   UCSC; uc011lbt.2; human.
DR   EuPathDB; HostDB:ENSG00000077782.19; -.
DR   HGNC; HGNC:3688; FGFR1.
DR   OpenTargets; ENSG00000077782; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000155860; -.
DR   HOVERGEN; HBG078771; -.
DR   ChiTaRS; FGFR1; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000077782; Expressed in 240 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; B5A958; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B5A958,
KW   ECO:0000213|PeptideAtlas:B5A958};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    228       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014567712.
FT   DOMAIN       67    155       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      164    200       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   228 AA;  25763 MW;  9ACD905A4E638639 CRC64;
     MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNPV
     APYWTSPEKM EKKLHAVPAA KTVKFKCPSS GTPNPTLRWL KNGKEFKPDH RIGGYKVRYA
     TWSIIMDSVV PSDKGNYTCI VENEYGSINH TYQLDVVERS PHRPILQAGL PANKTVALGS
     NVEFMCKVYS DPQPHIQWLK HIEVNGSKIG PDNLPYVQIL KPWKRGRQ
//