ID   B4E3H9_HUMAN            Unreviewed;       172 AA.
AC   B4E3H9;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 78.
DE   SubName: Full=cDNA FLJ51776, highly similar to Granulysin {ECO:0000313|EMBL:BAG65491.1};
GN   Name=GNLY {ECO:0000313|Ensembl:ENSP00000436423};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG65491.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436423, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|EMBL:BAG65491.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus {ECO:0000313|EMBL:BAG65491.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000436423}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC012454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK304728; BAG65491.1; -; mRNA.
DR   RefSeq; NP_001289687.1; NM_001302758.1.
DR   UniGene; Hs.105806; -.
DR   PeptideAtlas; B4E3H9; -.
DR   PRIDE; B4E3H9; -.
DR   Ensembl; ENST00000524600; ENSP00000436423; ENSG00000115523.
DR   GeneID; 10578; -.
DR   UCSC; uc010ysx.3; human.
DR   CTD; 10578; -.
DR   EuPathDB; HostDB:ENSG00000115523.16; -.
DR   HGNC; HGNC:4414; GNLY.
DR   OpenTargets; ENSG00000115523; -.
DR   eggNOG; ENOG410J70I; Eukaryota.
DR   eggNOG; ENOG41117YV; LUCA.
DR   GeneTree; ENSGT00390000002975; -.
DR   HOGENOM; HOG000112748; -.
DR   HOVERGEN; HBG005866; -.
DR   OMA; DGEQFCQ; -.
DR   OrthoDB; 1413739at2759; -.
DR   ChiTaRS; GNLY; human.
DR   GenomeRNAi; 10578; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115523; Expressed in 129 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; B4E3H9; baseline and differential.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   InterPro; IPR038847; Granulysin-like.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   PANTHER; PTHR15541; PTHR15541; 1.
DR   Pfam; PF03489; SapB_2; 1.
DR   SMART; SM00741; SapB; 1.
DR   SUPFAM; SSF47862; SSF47862; 1.
DR   PROSITE; PS50015; SAP_B; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B4E3H9,
KW   ECO:0000213|PeptideAtlas:B4E3H9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    172       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085120.
FT   DOMAIN       89    169       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
SQ   SEQUENCE   172 AA;  19266 MW;  D3B523F7363C620F CRC64;
     MATWALLLLA AMLLGNPGLE VSVSPKGKNT SGRESGFGWA IWMEGLVFSR LSPEYYDLAR
     AHLRDEEKSC PCLAQEGPQG DLLTKTQELG RDYRTCLTIV QKLKKMVDKP TQRSVSNAAT
     RVCRTGRSRW RDVCRNFMRR YQSRVTQGLV AGETAQQICE DLRLCIPSTG PL
//